{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:53:50Z","timestamp":1778630030324,"version":"3.51.4"},"reference-count":48,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2004,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To compare 2 techniques of inducing\ncombined renal insufficiency and systemic hypertension\nin cats.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u201422 cats 6 to 12 months of age.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedure<\/jats:bold>\n                    \u2014Cats were randomly assigned to 1 of 3\ngroups. Control (C) group cats had 2 intact kidneys,\nremnant kidney (RK) group cats underwent unilateral\npartial renal infarction and contralateral nephrectomy,\nand remnant-wrap (W) group cats underwent unilateral\npartial renal infarction and partial abtation and wrapping\nof the contralateral kidney. Systemic arterial blood\npressure (BP) was measured continuously by use of\nimplanted radiotelemetric devices. Renal function was\nassessed via determination of glomerular filtration\nrate, measurement of serum creatinine and BUN concentrations,\nand determination of urine protein-to-creatinine\nratio (UP\/C). Serum aldosterone concentration\nand plasma renin activity were measured on day 75.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014Systolic BP was significantly higher in\ngroups RK and W than in group C, and systolic BP\nwas significantly higher in group W than in group RK.\nSerum aldosterone concentration and plasma renin\nactivity were significantly higher in group W, compared\nwith groups C and RK. Glomerular filtration rate\nwas significantly lower in groups RK and W, compared\nwith group C. Histologic indices of renal injury\nand UP\/C were significantly higher in group W, compared\nwith groups C and RK.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Hypertensive\nrenal insufficiency in group W was characterized by\nmarked sustained systemic hypertension, decreased\nrenal function, proteinuria, activation of the reninangiotensin-aldosterone axis, and renal structural\ninjury. Results support the hypothesis that marked\nsystemic hypertension, activation of the reninangiotensin-\naldosterone axis, and proteinuria may\ndamage the kidney of cats with preexisting renal\ninsufficiency. 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