{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:10:04Z","timestamp":1775769004289,"version":"3.50.1"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2004,8,1]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:bold>\n \u2014To investigate the effects of administration\nof acepromazine on IV glucose tolerance tests\n(IVGTTs) in dogs.\n <\/jats:p>\n \n Animals<\/jats:bold>\n \u20148 male mixed-breed dogs.\n <\/jats:p>\n \n Procedure<\/jats:bold>\n \u2014With a 1-week interval between tests,\neach dog underwent (in random order) an IVGTT with\nor without pretest administration of acepromazine\nmaleate (0.1 mg\/kg, SC, 30 minutes prior to the start\nof the IVGTT). Food was withheld from the dogs for\n14 hours prior to each test. Blood samples were\nobtained at 20, 10, and 1 minute prior to and at 2, 3,\n4, 5, 6, 8, 10, 12, 14, 16, 19, 22, 25, 30, 40, 50, 60, 70,\n80, 90, 100, 120, 140, 160, and 180 minutes after\nadministration of glucose.\n <\/jats:p>\n \n Results<\/jats:bold>\n \u2014There were no significant differences in the\nbaseline (ie, after food was withheld) plasma glucose,\nlactate, and insulin concentrations between dogs\nundergoing the IVGTT and acepromazine-IVGTT; however,\nlower baseline free fatty acid concentration was\nobserved in acepromazine-treated dogs. Analysis of\ndata via the application of Bergman's minimal model of\nglucose kinetics revealed no differences in insulin sensitivity,\nacute insulin response to glucose, disposition\nindex, or glucose effectiveness between dogs treated\nor not treated with acepromazine before testing.\n <\/jats:p>\n \n Conclusions and Clinical Relevance<\/jats:bold>\n \u2014Results indicated\nthat in dogs undergoing IV glucose tolerance\ntesting, pretest administration of small doses of acepromazine\ncan be used as a means of chemical\nrestraint without interfering with results of the glucose\nmetabolism assessment. (\n Am J Vet Res<\/jats:italic>\n 2004;65:1124\u20131127)\n <\/jats:p>","DOI":"10.2460\/ajvr.2004.65.1124","type":"journal-article","created":{"date-parts":[[2005,12,22]],"date-time":"2005-12-22T04:00:20Z","timestamp":1135224020000},"page":"1124-1127","source":"Crossref","is-referenced-by-count":12,"title":["Investigation of the effect of acepromazine on intravenous glucose tolerance tests in dogs"],"prefix":"10.2460","volume":"65","author":[{"given":"Viorica","family":"Ionut","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erlinda L.","family":"Kirkman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard N.","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1_434","first-page":"12","author":"Paddleford RR","year":"1999","journal-title":"Philadelphia: WB Saunders 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