{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:09:53Z","timestamp":1784876993303,"version":"3.55.0"},"reference-count":48,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2004,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To evaluate relationships among various\ntechniques for monitoring anesthetic depth in sevoflurane-anesthetized dogs undergoing orthopedic\nsurgery.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u201410 dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedure<\/jats:bold>\n                    \u2014Dogs were medicated with acepromazine\n(0.05 mg\/kg, IM), buprenorphine (0.01 mg\/kg, IM), and\natropine (0.04 mg\/kg, IM). Anesthesia was induced and\nmaintained with sevoflurane. Cardiovascular and respiratory\nresponses were monitored. Anesthetic depth\nwas monitored by use of the bispectral index (BIS), and\na proprietary index was used to monitor activity of the\nautonomic nervous system.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014A significant decrease in BIS was seen\nafter induction but concurrent changes were not\nobserved for the other techniques. The proprietary\nindex increased significantly after intubation, but no\nchanges were seen for the other techniques. No significant\nchanges were detected during incision or\nwhen higher nociceptive stimuli were applied. We did\nnot identify a correlation between BIS and the proprietary\nindex, the proprietary index and hemodynamic\nvariables, or the BIS and hemodynamic variables during\ninduction and maintenance. A significant increase\nin the proprietary index and BIS was detected at the\ntime of resumption of reflexes. During anesthetic\nrecovery, a correlation was found between the proprietary\nindex and BIS but not between hemodynamic\nvariables and the other techniques.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014A significant\nincrease in the proprietary index, but not the BIS or\nhemodynamic variables, was detected during intubation.\nAnesthetic induction with sevoflurane did not\nprevent the sympathetic stimulus attributable to tracheal\nintubation. Monitoring of hemodynamic variables\ndoes not provide sufficient information to allow\nclinicians to evaluate stress during anesthetic recovery.\n(\n                    <jats:italic>Am J Vet Res<\/jats:italic>\n                    2004;65:1128\u20131135)\n                  <\/jats:p>","DOI":"10.2460\/ajvr.2004.65.1128","type":"journal-article","created":{"date-parts":[[2005,12,22]],"date-time":"2005-12-22T04:00:20Z","timestamp":1135224020000},"page":"1128-1135","source":"Crossref","is-referenced-by-count":22,"title":["Relationships between a proprietary index, bispectral index, and hemodynamic variables as a means for evaluating depth of anesthesia in dogs anesthetized with sevoflurane"],"prefix":"10.2460","volume":"65","author":[{"given":"Mar\u00eda S.","family":"Carrasco-Jim\u00e9nez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda F. 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