{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:52:26Z","timestamp":1760079146561,"version":"3.38.0"},"reference-count":8,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2004,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate the efficacy of ceftiofur crystalline-\nfree acid (CCFA) administered into the posterior\naspect of an ear for treatment of corneal ulceration\nassociated with naturally occurring infectious bovine\nkeratoconjunctivitis (IBK).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201478 beef calves located at Sierra Foothills\nField Station (SFS) and 52 calves located at a commercial\ndairy (CD). All calves were from 3 to 9\nmonths old.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014At each site, calves were randomly allocated\nto 1 of 2 treatment groups by use of a block\ndesign determined by corneal ulcer size. A single\ndose of CCFA (6.6 mg of ceftiofur equivalents\/kg, SC)\nwas administered into the posterior aspect of a pinna.\nA second group of calves received a single dose of\nvehicle (0.03 mL\/kg, SC; controls). Corneal ulcers\nwere photographed, and clinical signs were assessed\nin calves every 3 to 4 days for 21 days.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014A positive treatment effect was detected\nat SFS. Results at the CD were inconclusive\nbecause ulcer healing occurred rapidly in control and\nCCFA-treated calves. At SFS, treatment with CCFA\nresulted in shorter mean healing times, smaller\ncorneal ulcer surface area measurements, amelioration\nof ocular discharge and photophobia, and a 50%\nincrease in the percentage of calves healed by day\n14. After adjustment for initial corneal ulcer size,\ntreatment with CCFA resulted in a 4-fold increase in\nthe odds of corneal ulcer healing by day 14, compared\nwith controls.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014A single dose\nof CCFA administered into the posterior aspect of a\npinna had a positive treatment effect against naturally\noccurring IBK in calves with corneal ulcerations . 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