{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:33:38Z","timestamp":1778279618040,"version":"3.51.4"},"reference-count":21,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2004,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To determine effects of atracurium on\nintraocular pressure (IOP), eye position, and arterial\nblood pressure in eucapnic and hypocapnic dogs\nanesthetized with isoflurane.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u201416 dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedure<\/jats:bold>\n                    \u2014Ventilation during anesthesia was controlled\nto maintain PaCO\n                    <jats:sub>2<\/jats:sub>\n                    at 38 to 44 mm Hg in group-I dogs (n = 8) and 26 to 32 mm Hg in group-II dogs\n(8). Baseline measurements for IOP, systolic, diastolic,\nand mean arterial blood pressure, central venous\npressure (CVP), and heart rate (HR) were recorded.\nResponses to peroneal nerve stimulation were monitored\nby use of a force-displacement transducer.\nAtracurium (0.2 mg\/kg) was administered IV and measurements\nwere repeated at 1, 2, 3, and 5 minutes\nand at 5-minute intervals thereafter for 60 minutes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014Atracurium did not affect IOP, HR, or CVP.\nGroup II had higher CVP than group I, but IOP was not\ndifferent. There was no immediate effect of atracurium\non arterial blood pressure. Arterial blood pressure\nincreased gradually over time in both groups. Thirty\nseconds after administration of atracurium, the eye\nrotated from a ventromedial position to a central position\nand remained centrally positioned until 100%\nrecovery of a train-of-four twitch response. The time\nto 100% recovery was 53.1 \u00b1 5.3 minutes for group I\nand 46.3 \u00b1 9.2 minutes for group II.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Atracurium\ndid not affect IOP or arterial blood pressure in isoflurane-\nanesthetized dogs. Hyperventilation did not\naffect IOP or the duration of effect of atracurium. (\n                    <jats:italic>Am\nJ Vet Res<\/jats:italic>\n                    2004;65:179\u2013182)\n                  <\/jats:p>","DOI":"10.2460\/ajvr.2004.65.179","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T09:58:50Z","timestamp":1135159130000},"page":"179-182","source":"Crossref","is-referenced-by-count":22,"title":["Effects of atracurium on intraocular pressure, eye position, and blood pressure in eucapnic and hypocapnic isoflurane-anesthetized dogs"],"prefix":"10.2460","volume":"65","author":[{"given":"Rose M.","family":"McMurphy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harriet J.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David 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