{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:09:58Z","timestamp":1775768998309,"version":"3.50.1"},"reference-count":55,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2004,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To evaluate systemic effects of IV infusion\nof ATP-MgCl\n                    <jats:sub>2<\/jats:sub>\n                    subsequent to infusion of a low\ndose of endotoxin in horses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u201412 adult horses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedure<\/jats:bold>\n                    \u2014Horses were administered endotoxin\n(lipopolysaccharide [LPS]) or saline (0.9% NaCl) solution,\nIV, during a 30-minute period. Immediately thereafter,\nhorses in each group were infused IV with ATP-MgCl\n                    <jats:sub>2<\/jats:sub>\n                    or\nsaline solution. Two weeks later, horses were administered\nthe opposite solution (LPS or saline solution), but\nit was followed by the same infusion as 2 weeks previously\n(ie, ATP-MgCl\n                    <jats:sub>2<\/jats:sub>\n                    or saline solution). Cardiopulmonary\nand clinicopathologic variables, cytokine activity, and\nendothelin (ET) concentrations were recorded.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014IV infusion of ATP-MgCl\n                    <jats:sub>2<\/jats:sub>\n                    after administration\nof a low dose of endotoxin failed to attenuate the\ncardiopulmonary, clinicopathologic, and cytokine alterations\nthat develop secondary to endotoxin exposure.\nThe combination of LPS and ATP-MgCl\n                    <jats:sub>2<\/jats:sub>\n                    potentiated\npulmonary hypertension, leukopenia, and neutropenia\nwhen compared with the combination of LPS and\nsaline solution. The combination of LPS and ATP-MgCl\n                    <jats:sub>2<\/jats:sub>\n                    resulted in thrombocytopenia. Endothelin concentration\nwas increased in jugular venous and pulmonary\narterial plasma in horses receiving LPS and\nATP-MgCl\n                    <jats:sub>2<\/jats:sub>\n                    . Similar increases were not observed with\nLPS and saline solution.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Administration\nof ATP-MgCl\n                    <jats:sub>2<\/jats:sub>\n                    did not protect horses from systemic\neffects of experimentally induced endotoxemia.\nFurthermore, the use of ATP-MgCl\n                    <jats:sub>2<\/jats:sub>\n                    during endotoxemia\nmay worsen the cardiopulmonary and clinicopathologic\nstatus of affected horses. Because ATP and\nother adenine nucleotides are released from cells during\nshock, their potential role in the development of\nhemodynamic derangements, leukocyte adherence,\nand coagulopathies during endotoxemic episodes warrants\nfurther investigation. (\n                    <jats:italic>Am J Vet Res<\/jats:italic>\n                    2004;65:\n225\u2013237)\n                  <\/jats:p>","DOI":"10.2460\/ajvr.2004.65.225","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T09:58:50Z","timestamp":1135159130000},"page":"225-237","source":"Crossref","is-referenced-by-count":10,"title":["Effects of infusion of adenosine triphosphatemagnesium chloride on cardiopulmonary and clinicopathologic variables, cytokine activity, and endothelin concentration in horses administered a low dose of endotoxin"],"prefix":"10.2460","volume":"65","author":[{"given":"Joanne","family":"Tetens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rustin M.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle 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