{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T21:43:29Z","timestamp":1749851009424,"version":"3.38.0"},"reference-count":37,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2004,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate the efficacy of a customized\nsolution to attenuate intestinal injury following 20%\nlow-flow ischemia and reperfusion in the jejunum of\nhorses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201410 healthy adult horses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Two 30.5-cm-long segments of jejunum\nwere exteriorized through a ventral midline incision\nand the mesenteric artery and vein supplying that portion\nof the intestine were instrumented with flow\nprobes. Blood flow was decreased to 20% of baseline\nfor 90 minutes followed by 90 minutes of reperfusion.\nIn 5 horses, 60 mL of the customized solution\nwas placed in the lumen of each segment (treatment-group\nhorses), and 60 mL of lactated Ringer's solution\nwas placed in the lumen of 5 additional horses\n(control-group horses). Biopsy specimens were\nobtained from 1 segment in both groups for histologic\nevaluation. Aliquots of luminal fluid were obtained\nfrom the other segment in both groups for determination\nof albumin concentrations as an index of\nmucosal permeability.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Compared with control-group horses, treatment-group horses had a significant decrease in luminal\nalbumin concentration following reperfusion.\nAlthough differences in mucosal grades were not significantly\ndifferent between control- and treatment-group\nhorses, treatment-group horses had significantly\ngreater jejunal villous length and area, compared\nwith that of control-group horses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Intraluminal\nadministration of the customized solution in the\njejunum, compared with lactated Ringer's solution,\nresults in an improvement in histologic findings and\nmucosal translocation of albumin in horses with mild\nintestinal injury. 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