{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:50:09Z","timestamp":1759938609255,"version":"3.38.0"},"reference-count":24,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2004,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To macroscopically, histomorphologically,\nand morphometrically compare uterine tissues\nobtained from nulliparous and multiparous dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201412 dogs constituting 2 homogenous\ngroups (7 nulliparous Beagles and 5 multiparous\nBeagles, each of which had at least 7 pregnancies).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Serum concentrations of progesterone\nand estradiol-17\u03b2 were determined. Samples of uterine\ntissues were fixed, embedded in paraffin, and cut\ninto serial cross sections. Morphometric analysis was\nperformed on systematically selected trichromestained\nsections.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Mean absolute volume of the uterine wall\ndid not differ between groups. Volume of blood vessels\nwas significantly higher and relative mean value\nfor myometrial connective tissue was significantly\nlower in the multiparous dogs. Arteries in the\nmyometrium of multiparous dogs had pronounced\nthickening of the intima (ie, pregnancy sclerosis) and\na concomitant thinning of the smooth muscle layer\n(tunica media). Furthermore, the elastica interna of\nthese arteries appeared to be disintegrating and was\nhighly and irregularly folded. Adventitia of the myometrial\nveins in multiparous dogs contained numerous\nlayers of elastic fibers; however, only a few layers\nwere observed in the adventitia of corresponding\nveins in nulliparous dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014In this study,\nwe documented that in contrast to other species, the\nuterus of nonpregnant dogs does not increase in size\nand volume even after at least 7 pregnancies.\nFurthermore, sclerotic alterations of uterine arteries\nare proof of at least 1 pregnancy. Results of this study\nmay be useful in the evaluation of uterine diseases.\n( <jats:italic>Am J Vet Res<\/jats:italic> 2004;65:552\u2013558)<\/jats:p>","DOI":"10.2460\/ajvr.2004.65.552","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T12:18:48Z","timestamp":1135167528000},"page":"552-558","source":"Crossref","is-referenced-by-count":7,"title":["Histomorphologic and morphometric evaluation of the uterine horns in nulliparous and multiparous Beagles"],"prefix":"10.2460","volume":"65","author":[{"given":"Heinz R.","family":"Augsburger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"K\u00fcrzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1_79","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1113\/jphysiol.1954.sp005066","volume":"123","author":"Harkness ML","year":"1954","journal-title":"J Physiol"},{"key":"p_2_80","first-page":"1240","volume":"10","author":"Montford I","year":"1961","journal-title":"Lab Invest"},{"key":"p_3_81","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3168\/jds.S0022-0302(66)87924-9","volume":"49","author":"Mochow R","year":"1966","journal-title":"J Dairy Sci"},{"key":"p_4_82","first-page":"122","volume":"41","author":"Nishinaka K","year":"1991","journal-title":"Acta Pathol Jpn"},{"key":"p_5_83","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod47.5.698"},{"key":"p_6_84","first-page":"87","volume":"26","author":"Kaidi R","year":"1995","journal-title":"Vet Res"},{"key":"p_7_85","doi-asserted-by":"publisher","DOI":"10.1053\/rvsc.2000.0443"},{"key":"p_8_86","first-page":"223","author":"Woessner JF","year":"1980","journal-title":"UK: John Wiley & Sons"},{"key":"p_9_87","first-page":"217","volume":"45","author":"Al-Bassam MA","year":"1981","journal-title":"Can J Comp Med"},{"key":"p_10_88","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0934-8832(11)80213-1","volume":"11","author":"Kaidi R","year":"1991","journal-title":"Matrix"},{"key":"p_11_89","first-page":"125","author":"McEntee K.","year":"1990","journal-title":"New York: Academic Press Inc"},{"key":"p_12_90","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0021-9975(98)80051-0","volume":"119","author":"Gruninger B","year":"1998","journal-title":"J Comp Pathol"},{"key":"p_13_91","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0021-9975(08)80214-9","volume":"108","author":"Oikawa M","year":"1993","journal-title":"J Comp Pathol"},{"key":"p_14_92","unstructured":"Romeis B, Bock P. 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