{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T05:22:35Z","timestamp":1741411355827,"version":"3.38.0"},"reference-count":14,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2004,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To examine effects of danofloxacin and\ntilmicosin on continuously recorded body temperature\nin beef calves with pneumonia experimentally\ninduced by inoculation of <jats:italic>Mannheimia haemolytica<\/jats:italic>.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201441 Angus-cross heifers (body weight, 160 to\n220 kg) without a recent history of respiratory tract disease\nor antimicrobial treatment, all from a single ranch.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Radiotransmitters were implanted intravaginally\nin each calf. Pneumonia was induced intrabronchially\nby use of logarithmic-phase cultures of\n<jats:italic>M haemolytica<\/jats:italic>. At 21 hours after inoculation, calves\nwere treated with saline (0.9% NaCl) solution,\ndanofloxacin, or tilmicosin. Body temperature was\nmonitored from 66 hours before inoculation until 72\nhours after treatment. Area under the curve (AUC) of\nthe temperature-time plot and mean temperature\nwere calculated for 3-hour intervals and compared\namong treatment groups.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014The AUCs for 3-hour intervals did not differ\nsignificantly among treatment groups for any of the\ntime periods. Analysis of the mean temperature for\n3-hour intervals revealed significantly higher temperatures\nat most time periods for saline-treated calves,\ncompared with temperatures for antimicrobial-treated\ncalves; however, we did not detect significant differences\nbetween the danofloxacin- and tilmicosin-treated\ncalves. The circadian rhythm of temperatures\nbefore exposure was detected again approximately\n48 hours after bacterial inoculation.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Danofloxacin\nand tilmicosin did not differ in their effect on mean\nbody temperature for 3-hour intervals but significantly\ndecreased body temperature, compared with body\ntemperature in saline-treated calves. Normal daily\nvariation in body temperature must be considered in\nthe face of respiratory tract disease during clinical\nevaluation of feedlot cattle. 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