{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T21:57:48Z","timestamp":1770587868124,"version":"3.49.0"},"reference-count":10,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2004,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine the effects of 2 anti-inflammatory\ndrugs in lactating Holstein cows with endotoxin-\ninduced mastitis.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201430 multiparous Holstein cows that had\nbeen lactating for 30 to 60 days.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Bacterial culture of milk samples and\nphysical examinations established that study cows\nwere in good health and free of mastitis. Mastitis was\ninduced in 1 front mammary gland by intramammary\nadministration of purified bacterial endotoxin. Cows\nwere allocated into 1 of 3 treatment groups: untreated\nendotoxic mastitis (n = 9), endotoxic mastitis plus\nflunixin meglumine (9), and endotoxic mastitis plus\nisoflupredone acetate (10). Heart rate, rectal temperature,\nmammary surface area, and rumen motility\nwere recorded hourly for 14 hours following endotoxin\nadministration. Flunixin meglumine or isoflupredone\nacetate was administered after mammary\nswelling and rectal temperature \u2265 40\u00b0C had developed.\nMilk production was evaluated from 5 days\nbefore to 10 days after induction of mastitis.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Neither drug ameliorated loss of milk production\nor swelling of the affected mammary gland.\nBoth drugs reduced mean heart rate during the 14\nhours following endotoxin administration, compared\nwith untreated control cows. Cows treated with flunixin\nmeglumine had increased rumen motility and\ndecreased rectal temperature during the same period,\ncompared with all other cows.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Neither drug\nenhanced recovery of milk production following endotoxin-\ninduced mastitis. Flunixin meglumine decreased\nrectal temperature, whereas isoflupredone did not;\nhowever, it has not been established that reduction of\nfever is beneficial to cows with naturally occurring\nmastitis. 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