{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:02:17Z","timestamp":1784401337043,"version":"3.55.0"},"reference-count":48,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2004,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine the neurologic effects of\nreduced intake of phenylalanine and tyrosine in black-haired\ncats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201453 specific pathogen-free black domestic\nshorthair cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Cats were fed purified diets containing\nvarious concentrations of phenylalanine and tyrosine\nfor \u2264 9 months. Blood samples were obtained every 2\nmonths for evaluation of serum aromatic amino acid\nconcentrations. Cats were monitored for changes in\nhair color and neurologic or behavioral abnormalities.\nThree cats with neurologic deficits underwent clinical\nand electrophysiologic investigation; muscle and\nnerve biopsy specimens were also obtained from\nthese cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014After 6 months, neurologic and behavioral\nabnormalities including vocalization and abnormal\nposture and gait were observed in cats that had\nreceived diets containing &lt; 16 g of total aromatic\namino acid\/kg of diet. Electrophysiologic data and\nresults of microscopic examination of muscle and\nnerve biopsy specimens from 3 cats with neurologic\nsigns were consistent with sensory neuropathy with\nprimary axonal degeneration. Changes in hair color\nwere detected in cats from all groups receiving &lt; 16\ng of phenylalanine plus tyrosine\/kg of diet.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Findings suggested\nthat chronic dietary restriction of phenylalanine\nand tyrosine in cats may result in a predominantly\nsensory neuropathy. In cats, the long-term\nnutritional requirement for phenylalanine and tyrosine\nappears to be greater for normal neurologic function\nthan that required in short-term growth experiments.\nOfficial present-day recommendations for dietary\nphenylalanine and tyrosine in cats may be insufficient\nto support normal long-term neurologic function. 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