{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:24:38Z","timestamp":1759335878533,"version":"3.38.0"},"reference-count":46,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2005,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate the effects of nephrotomy on\nrenal function in clinically normal cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201420 specific-pathogen-free, 9- to 11-month old\nfemale mixed-breed cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Serum chemistry analyses, CBC determinations,\nurinalyses, microbiologic urine cultures,\nrenal ultrasonography, abdominal radiography, and\nsingle-kidney and total glomerular filtration rate (GFR)\ndeterminations by use of renal scintigraphy and measurements\nof plasma disappearance of technetium\n99m-diethylenetriaminepentaacetic acid were performed\nbefore surgery and at 3, 12, 26, 52, and 78\nweeks after surgery in 10 cats that underwent unilateral\nnephrotomy and in 10 control cats that underwent\na sham surgical procedure.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Two cats (1 from each group) did not complete\nthe study, and their data were eliminated from\nanalyses. Unilateral nephrotomy resulted in a 10% to\n20% reduction in mean single-kidney GFR, compared\nwith that of nephrotomy contralateral control kidneys.\nHowever, mean total GFR in nephrotomy-group cats\nwas not significantly different from that of shamgroup\ncats. Over the 78 weeks of study, mean total\nGFR declined 34% and 40% in nephrotomy- and\nsham-group cats, respectively. Adverse events associated\nwith nephrotomy included persistent microscopic\nhematuria, renal pelvis hyperechogenicity with\ndistant shadowing on ultrasonographic evaluation,\ndilatation of renal pelves, and hydronephrosis.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Nephrotomy\nin normal functioning feline kidneys results in a modest\nrelative reduction in renal function, compared with\ncontralateral kidney controls, but has minimal effect\non total GFR when compared with sham-operated\ncontrol cats. However, any detrimental effects of\nnephrotomy may be magnified in cats with diseased\nkidneys, which may have little or no capacity for repair\nor compensation. 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