{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T02:42:37Z","timestamp":1772678557998,"version":"3.50.1"},"reference-count":45,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2005,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To assess associations between epidemiologic\nand laboratory variables and calciotropic\nhormones in cats with odontoclastic resorptive\nlesions (ORLs).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014182 client-owned cats older than 1 year of\nage with oral disease.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Information on medical history, behavior,\nliving environment, and feeding management was\nassessed by use of a questionnaire. After induction of\ngeneral anesthesia, oral examination was performed\nfollowing standardized protocols and included dental\nprobing and full-mouth radiography. Laboratory analyses\nincluded evaluation of FeLV-FIV status, serum biochemical\nanalyses, CBC, urinalysis, and serum concentrations\nof intact parathyroid hormone (iPTH),\nparathyroid hormone-related peptide (PTHrP), 25-hydroxyvitamin D (25-OHD), free thyroxine (fT<jats:sub>4<\/jats:sub>), and\nionized calcium (iCa).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014ORLs were identified in 72.5% of cats.\nMandibular third premolars were the most commonly\naffected teeth. Cats with ORLs were significantly\nolder (mean, 9.2 years) than cats without ORLs\n(mean, 6.6 years). Multivariate logistic regression\nanalysis revealed that 25-OHD, urine specific gravity,\njaw-opening reflex on probing, and missing teeth\nwere significant variables, even after accounting for\nage. Cats with ORLs had significantly higher mean\nserum concentration of 25-OHD (112.4 nmol\/L) and\nsignificantly lower mean urine specific gravity\n(1.0263), compared with cats without ORLs (89.8\nnmol\/L and 1.0366, respectively).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results did\nnot indicate associations between iPTH, PTHrP, or fT<jats:sub>4<\/jats:sub>\nand development of ORLs. In affected cats, the\nimportance of high serum 25-OHD and low urine specific\ngravity has not been determined. 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