{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:10:26Z","timestamp":1775769026944,"version":"3.50.1"},"reference-count":19,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2005,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To compare myocardial concentrations of\nfatty acids in dogs with dilated cardiomyopathy (DCM)\nwith concentrations in control dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Sample Population<\/jats:bold>\n                    \u2014Myocardial tissues from 7\ndogs with DCM and 16 control dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedure<\/jats:bold>\n                    \u2014Myocardial tissues were homogenized,\nand total fatty acids were extracted and converted to\nmethyl esters. Myocardial concentrations of fatty\nacids were analyzed by use of gas chromatography\nand reported as corrected percentages.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014The amount of docosatetraenoic acid\n(C22:4 n-6) was significantly higher in myocardial samples\nfrom dogs with DCM (range, 0.223% to 0.774%;\nmedian, 0.451%), compared with the amount in samples\nobtained from control dogs (range, 0.166% to\n0.621%; median, 0.280%). There were no significant\ndifferences between DCM and control dogs for concentrations\nof any other myocardial fatty acids.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Although concentrations\nof most myocardial fatty acids did not differ\nsignificantly between dogs with DCM and control\ndogs, the concentration of docosatetraenoic acid was\nsignificantly higher in dogs with DCM. Additional\ninvestigation in a larger population is warranted to\ndetermine whether this is a primary or secondary\neffect of the underlying disease and whether alterations\nin fatty acids may be a target for intervention in\ndogs with DCM. (\n                    <jats:italic>Am J Vet Res<\/jats:italic>\n                    2005;66:1483\u20131486)\n                  <\/jats:p>","DOI":"10.2460\/ajvr.2005.66.1483","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T07:25:59Z","timestamp":1135149959000},"page":"1483-1486","source":"Crossref","is-referenced-by-count":2,"title":["Myocardial concentrations of fatty acids in dogs with dilated cardiomyopathy"],"prefix":"10.2460","volume":"66","author":[{"given":"Caren E.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Meydani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Rush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0195-5616(91)50107-8","volume":"21","author":"Harpster NK","year":"1991","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.218.729"},{"key":"p_3","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2460\/javma.1997.210.04.505","volume":"210","author":"Calvert CA","year":"1997","journal-title":"J Am Vet Med Assoc"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1016\/S1760-2734(06)70019-4"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1995.tb03266.x"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1998.tb02148.x"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1994.1155"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6363(96)88610-X"},{"key":"p_9","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1161\/01.CIR.94.11.2837","volume":"94","author":"Sack MN","year":"1996","journal-title":"Circulation"},{"key":"p_10","first-page":"124","volume":"42","author":"Kataoka K","year":"2001","journal-title":"J Nucl Med"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01967-8"},{"key":"p_12","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/cvr\/28.3.407","volume":"28","author":"Lax D","year":"1994","journal-title":"Cardiovasc Res"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1016\/0952-3278(95)90023-3"},{"key":"p_14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/labinvest.3780427","volume":"82","author":"Bissler JJ","year":"2002","journal-title":"Lab Invest"},{"key":"p_15","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0005-2760(80)90176-9","volume":"617","author":"Van der Vusse GJ","year":"1980","journal-title":"Biochim Biophys Acta"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000118494.07530.65"},{"key":"p_17","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/0005-2760(75)90186-1","volume":"398","author":"Bernert","year":"1975","journal-title":"Biochim Biophys Acta"},{"key":"p_18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0005-2760(86)90165-7","volume":"875","author":"Hagve TA","year":"1986","journal-title":"Biochim Biophys Acta"},{"key":"p_19","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.2460\/javma.1998.212.11.1732","volume":"212","author":"Tidholm A","year":"1998","journal-title":"J Am Vet Med Assoc"}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/66\/9\/ajvr.2005.66.1483.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/66\/9\/ajvr.2005.66.1483.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/66\/9\/ajvr.2005.66.1483.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:10:06Z","timestamp":1775765406000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/66\/9\/ajvr.2005.66.1483.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,1]]},"references-count":19,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.2005.66.1483","relation":{},"ISSN":["0002-9645"],"issn-type":[{"value":"0002-9645","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9,1]]}}}