{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:10:26Z","timestamp":1775769026936,"version":"3.50.1"},"reference-count":36,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2005,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To quantify and compare biochemical\ncharacteristics of the extracellular matrix (ECM) of\nspecimens harvested from tensional and compressive\nregions of the superficial digital flexor tendon\n(SDFT) of horses in age classes that include neonates\nto mature horses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Sample Population<\/jats:bold>\n                    \u2014Tendon specimens were collected\non postmortem examination from 40 juvenile\nhorses (0, 5, 12, and 36 months old) without macroscopically\nvisible signs of tendonitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedure<\/jats:bold>\n                    \u2014Central core specimens of the SDFT\nwere obtained with a 4-mm-diameter biopsy punch\nfrom 2 loaded sites, the central part of the midmetacarpal\nregion and the central part of the midsesamoid\nregion. Biochemical characteristics of the\ncollagenous ECM content (ie, collagen, hydroxylysylpyridinoline\ncrosslink, and pentosidine crosslink\nconcentrations and percentage of degraded collagen)\nand noncollagenous ECM content (percentage of\nwater and glycosaminoglycans, DNA, and hyaluronic\nacid concentrations) were measured.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014The biochemical composition of equine\nSDFT was not homogeneous at birth with respect to\nDNA, glycosaminoglycans, and pentosidine concentrations.\nFor most biochemical variables, the amounts\npresent at birth were dissimilar to those found in\nmature horses. Fast and substantial changes in all\ncomponents of the matrix occurred in the period of\ngrowth and development after birth.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Unlike cartilage,\ntendon tissue is not biochemically blank (ie, homogeneous)\nat birth. However, a process of functional adaptation\noccurs during maturation that changes the composition\nof equine SDFT from birth to maturity.\nUnderstanding of the maturation process of the juvenile\nequine SDFT may be useful in developing exercise programs\nthat minimize tendon injuries later in life that\nresult from overuse. (\n                    <jats:italic>Am J Vet Res<\/jats:italic>\n                    2005;66:1623\u20131629)\n                  <\/jats:p>","DOI":"10.2460\/ajvr.2005.66.1623","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T07:25:59Z","timestamp":1135149959000},"page":"1623-1629","source":"Crossref","is-referenced-by-count":14,"title":["Functional adaptation through changes in regional biochemical characteristics during maturation of equine superficial digital flexor tendons"],"prefix":"10.2460","volume":"66","author":[{"given":"Yi-lo","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter A. 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