{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:24:41Z","timestamp":1790555081755,"version":"4.1.0"},"reference-count":18,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2005,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate serum titers obtained by use\nof the microscopic agglutination test (ie, MAT titers)\nto <jats:italic>Leptospira interrogans<\/jats:italic> serovar pomona and autumnalis\nand <jats:italic>Leptospira kirschneri<\/jats:italic> serovar grippotyphosa\nin dogs given a commercial vaccine against serovars\npomona and grippotyphosa.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014Forty 12-week-old puppies and 20 mature\nBeagles.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Puppies received a commercial vaccine\nagainst serovars pomona and grippotyphosa at 12 weeks\nof age, then received a booster vaccine and 3 weeks\nlater; mature dogs received the vaccine once. Serum\nMAT titers to serovars pomona, autumnalis, and grippotyphosa\nwere measured before vaccination and at 2, 4, 6,\n10, and 16 weeks after the first or only vaccination.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Of the 40 puppies vaccinated, 40, 0, and 40\ndeveloped MAT titers of &gt; 100 after vaccination to\nserovars pomona, grippotyphosa, and autumnalis,\nrespectively. Microscopic agglutination test titers to\nserovar autumnalis were higher than MAT titers to\nserovars pomona and grippotyphosa and persisted in\nsome dogs for 16 weeks (6 weeks longer than for\ntiters to serovar pomona). Of the 20 mature dogs, 13,\n5, and 20 developed MAT titers of &gt; 100 at 2 weeks\nto serovars pomona, grippotyphosa, and autumnalis,\nrespectively. Titers to serovar pomona were higher\nand persisted in some dogs beyond 16 weeks after\nvaccination, compared with titers to serovars pomona\nand grippotyphosa, which persisted for 10 and 6\nweeks, respectively.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Subunit vaccines\nagainst serovars pomona and grippotyphosa\ninduce MAT titers not only to homologous antigens\nbut also to serovar autumnalis, which could lead to a\nmisdiagnosis of leptospirosis caused by serovar\nautumnalis. (<jats:italic>Am J Vet Res<\/jats:italic> 2005;66:1780\u20131784)<\/jats:p>","DOI":"10.2460\/ajvr.2005.66.1780","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T12:01:39Z","timestamp":1135166499000},"page":"1780-1784","source":"Crossref","is-referenced-by-count":48,"title":["Serologic responses of dogs given a commercial vaccine against Leptospira interrogans serovar pomona and Leptospira kirschneri serovar grippotyphosa"],"prefix":"10.2460","volume":"66","author":[{"given":"Stephen C.","family":"Barr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick L.","family":"McDonough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta L.","family":"Scipioni-Ball","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Starr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2460\/javma.1991.199.03.351","volume":"199","author":"Nielson JN","year":"1991","journal-title":"J Am Vet Med Assoc"},{"key":"p_2","first-page":"405","volume":"11","author":"Newman JP","year":"1950","journal-title":"Am J Vet Res"},{"key":"p_3","first-page":"145","volume":"19","author":"Murphy LC","year":"1958","journal-title":"Am J Vet Res"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1992.tb00345.x"},{"key":"p_5","doi-asserted-by":"crossref","first-page":"495","DOI":"10.5326\/15473317-32-6-495","volume":"32","author":"Harkin KR","year":"1996","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_6","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.2460\/javma.1996.209.07.1265","volume":"209","author":"Brown CA","year":"1996","journal-title":"J Am Vet Med Assoc"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1998.tb03640.x"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2000.216.371"},{"key":"p_9","first-page":"430","volume":"40","author":"Prescott JF","year":"1999","journal-title":"Can Vet J"},{"key":"p_10","first-page":"187","volume":"40","author":"Kalin M","year":"1999","journal-title":"Can Vet J"},{"key":"p_11","first-page":"273","author":"Greene CE","year":"1998","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_12","first-page":"1215","volume":"18","author":"Wohl JS","year":"1996","journal-title":"Compend Contin Educ Pract Vet"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-2867(96)80029-6"},{"key":"p_14","first-page":"494","volume":"41","author":"Ribotta M","year":"2000","journal-title":"Can Vet J"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1136\/vr.153.6.165"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(03)00152-4"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(84)90083-7"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(65)90003-4"}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/66\/10\/ajvr.2005.66.1780.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/66\/10\/ajvr.2005.66.1780.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/66\/10\/ajvr.2005.66.1780.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T12:08:36Z","timestamp":1741349316000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/66\/10\/ajvr.2005.66.1780.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,1]]},"references-count":18,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.2005.66.1780","relation":{},"ISSN":["0002-9645"],"issn-type":[{"value":"0002-9645","type":"print"}],"subject":[],"published":{"date-parts":[[2005,10,1]]}}}