{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T05:23:50Z","timestamp":1741411430673,"version":"3.38.0"},"reference-count":26,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2005,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To compare the distribution of\ndesmoglein (Dsg) 1 and 2 in skin specimens obtained\nfrom dogs and cats to provide information about the\npossible role of the density of Dsg 1 and 2 in the localization\nof lesions attributable to pemphigus foliaceus\nin these 2 species.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Sample Population<\/jats:bold>\u2014Skin biopsy specimens\nobtained from 4 dogs and 4 cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Biopsy specimens were collected from\nthe muzzle, bridge of the nose, ear, dorsum,\nabdomen, area adjacent to the teats, and footpads of\neach animal. Immunohistochemical analysis was performed\non formalin-fixed, paraffin-embedded skin\nsamples by use of a biotinylated mouse monoclonal\nanti-Dsg 1 and 2 antibody raised against bovine muzzle.\nColor development was performed by use of the\nstreptavidin-biotin-peroxidase method with a chromogenic\nsubstrate.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Immunohistochemical staining yielded a\npositive reaction in skin samples obtained from all\nanatomic sites. The intensity and distribution of staining\nwere related to the number of layers of the stratum\nspinosum. No differences were detected\nbetween samples obtained from dogs and cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014No differences\nin intensity of Dsg 1 and 2 antigen were observed in\nthe stratum spinosum between skin samples obtained\nfrom dogs and cats. Analysis of this result suggests\nthat factors other than the distribution of Dsg may be\nresponsible for the differences in localization of primary\nclinical lesions in dogs and cats with pemphigus foliaceus.\n(<jats:italic>Am J Vet Res<\/jats:italic> 2005;66:1931\u20131935)<\/jats:p>","DOI":"10.2460\/ajvr.2005.66.1931","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T15:04:40Z","timestamp":1135177480000},"page":"1931-1935","source":"Crossref","is-referenced-by-count":4,"title":["Immunohistochemical analysis of the distribution of desmoglein 1 and 2 in the skin of dogs and cats"],"prefix":"10.2460","volume":"66","author":[{"given":"Vincenzo","family":"Miragliotta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Coli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria P.","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Podest\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Abramo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1_396","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1997.3890"},{"key":"p_2_397","first-page":"1","author":"Scott DW","year":"2001","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_3_398","first-page":"603","volume":"42","author":"Cozzani E","year":"1994","journal-title":"Pathol Biol (Paris)"},{"key":"p_4_399","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3164.1997.d01-5.x"},{"key":"p_5_400","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1242\/jcs.112.23.4325","volume":"112","author":"North AJ","year":"1999","journal-title":"J Cell Sci"},{"key":"p_6_401","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01400.x"},{"key":"p_7_402","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02604.x"},{"key":"p_8_403","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1346-8138.2001.tb00136.x","volume":"28","author":"McMillan JR","year":"2001","journal-title":"J Dermatol"},{"key":"p_9_404","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1172\/JCI10305","volume":"106","author":"Nguyen VT","year":"2000","journal-title":"J Clin Invest"},{"key":"p_10_405","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12513454"},{"key":"p_11_406","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJM198205203062001","volume":"306","author":"Anhalt GJ","year":"1982","journal-title":"N Engl J Med"},{"key":"p_12_407","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1242\/jcs.113.10.1803","volume":"113","author":"Hanakawa Y","year":"2000","journal-title":"J Cell Sci"},{"key":"p_13_408","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19648.x"},{"key":"p_14_409","doi-asserted-by":"publisher","DOI":"10.1007\/BF00558008"},{"key":"p_15_410","unstructured":"Suter MM, Ziegra CJ, Cayatte SM, etal Identification of canine pemphigus antigens. 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