{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:56:29Z","timestamp":1791384989115,"version":"4.3.3"},"reference-count":27,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2005,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To assess gross and histologic tissue\nresponses of skin incisions closed by use of\nabsorbable subcuticular staples, cutaneous metal staples,\nand polyglactin 910 suture in pigs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20148 purpose-bred disease-free pigs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Pigs were randomly allocated to 1 of 4\ngroups from which tissues were collected after\ndeath on postoperative days (PODs) 7, 14, 21, or\n42. In each pig, 4 incisions were made; 1 was\nclosed subcuticularly with 3-0 polyglactin 910\nsuture, 1 was closed with metal staples, and 2\nwere closed with absorbable subcuticular staples.\nIncision sites were grossly evaluated every 3 days\nafter closure. At necropsy, incision sites and surrounding\ntissues were examined histologically; a\nhistopathologic scoring system was used to quantitate\nhealing and tissue response directed against\nthe closure material.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Postoperatively, the metal staples induced\na severe inflammatory response, compared with minimal\ninflammation associated with the suture or\nabsorbable subcuticular staples. Histologic evaluation\nof incisions on PODs 7, 14, and 21 revealed less\nsevere inflammation associated with absorbable subcuticular\nstaples than that associated with the other\nmaterials.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results indicated\nthat absorbable subcuticular staples induced a\nless severe inflammatory response in the early\nstages of healing in pigs, compared with other commonly\nused methods of wound closure. Use of\nabsorbable staples potentially combines the benefits\nof subcuticular closure with the speed and precision\nof staple placement. 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