{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:27:06Z","timestamp":1790940426483,"version":"4.1.0"},"reference-count":14,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2005,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To validate use of magnetic resonance\nimages (MRIs) for measurement of equine articular\ncartilage and subchondral bone thickness by\ncomparison with measurements in histologic\nspecimens.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Sample Population<\/jats:bold>\u201432 cadaveric carpal joints from\n16 horses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Magnetic resonance imaging was performed\nby use of 3-dimensional fast spoiled gradient\necho (SPGR) and T2* 3-dimensional fast gradient\necho (GRE) pulse sequences with and without fat\nsaturation. Standard sites on the medial and lateral\nfacets of the intermediate, radial, and third carpal\nbones were used for subchondral bone and articular\ncartilage thickness measurements. Digital image\nanalysis software was used for MRI measurements\n10 mm from the dorsal extent and perpendicular to\nthe articular surface. Histomorphometric measurements\nof hyaline, calcified cartilage, and subchondral\nbone thickness were obtained at selected sites.\nComparisons between histomorphometric and MRI\nmeasurements and between magnetic resonance\npulse sequences were evaluated.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014There were significant correlations\nbetween GRE and SPGR and SPGR and histologic\nmeasurements of articular cartilage, with no significant\ndifference between measurements and good\nagreement. When calcified cartilage was excluded\nfrom the histologic measurement, MRI measurements\nwere significantly greater than histologic measurements.\nFor subchondral bone thickness, there\nwas significant correlation between GRE and SPGR\nbut GRE was significantly greater than SPGR measurements.\nHistomorphometric and MRI measurements\nwere strongly correlated and not significantly\ndifferent.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Magnetic resonance\nimaging provides a good representation of\ncartilage and subchondral bone thickness, supporting\nits use in the study and clinical diagnosis of osteochondral\nstructure and alteration. 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