{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:48:49Z","timestamp":1791053329663,"version":"4.1.0"},"reference-count":29,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2005,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To assess the potential clinical relevance\nof seroreactivity to <jats:italic>Bartonella henselae<\/jats:italic> antigens in\ndogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201440 dogs seroreactive to <jats:italic>B henselae<\/jats:italic> and 45\ndogs that did not seroreact to <jats:italic>B henselae<\/jats:italic>.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014A case-control study was conducted.\nClinical and clinicopathologic findings were extracted\nfrom medical records of each dog.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Statistical differences were not detected\nbetween dogs seroreactive or nonseroreactive to\n<jats:italic>B henselae<\/jats:italic> when analyzed on the basis of disease\ncategory or results of hematologic, biochemical,\nurine, or cytologic analysis. However, seroreactivity\nto <jats:italic>B henselae<\/jats:italic> antigens was detected in 2 of 4 dogs\nwith a clinical diagnosis of granulomatous meningoencephalitis,\n3 of 4 dogs with immune-mediated\nhemolytic anemia, 3 of 4 dogs with infective endocarditis,\n2 of 3 dogs with lymphoid neoplasia, and 5\nof 10 dogs with polyarthritis. Additionally, seroreactivity\nto <jats:italic>B henselae<\/jats:italic> antigens was detected in 18 of\n34 thrombocytopenic dogs and 14 of 27 dogs with\nneutrophilia.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Significant\nassociations were not detected between seroreactivity\nto <jats:italic>B henselae<\/jats:italic> and various diseases. Prospective\nepidemiologic studies investigating specific diseases,\nsuch as meningoencephalitis or polyarthritis, and specific\nhematologic abnormalities, such as immunemediated\nhemolytic anemia or thrombocytopenia,\nshould be conducted to further define the potential\nclinical relevance of antibodies against <jats:italic>B henselae<\/jats:italic> in\ndogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Impact for Human Medicine<\/jats:bold>\u2014<jats:italic>Bartonella<\/jats:italic> organisms\nare increasingly reported as pathogens that induce\nare increasingly reported as pathogens that induce\nchronic infections in humans and dogs. Dogs may\nserve as natural candidates for future study of the disease\nin humans. 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