{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:10:33Z","timestamp":1775769033060,"version":"3.50.1"},"reference-count":23,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2005,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objectives<\/jats:bold>\n                    \u2014To determine whether increased glucose\nmetabolism is the potential cause of the\ndecreased plasma glucose curve determined after\noral glucose tolerance testing in horses with lower\nmotor neuron degeneration.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u20143 horses with signs suggestive of lower\nmotor neuron degeneration, 1 horse with malignant\nmelanoma with multiple metastases, and an obese\nbut otherwise healthy horse.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedures<\/jats:bold>\n                    \u2014Glucose metabolism was assessed by\nuse of the hyperglycemic clamp and euglycemic\nhyperinsulinemic clamp techniques.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014Mean rate of glucose metabolism of\nhorses with lower motor neuron degeneration was\nsignificantly greater (mean, 3.7 times greater than\ncontrol horses; range, 2.1 to 4.8 times greater)\nthan that reported in 5 healthy control horses\n(41 \u00b1 13 \u00b5mol\/kg\/min vs 11 \u00b1 4.5 \u00b5mol\/kg\/min,\nrespectively). In addition, one of the affected horses,\nan 8-year-old warmblood gelding, had a 5.6-\ntimes increased sensitivity to exogenously administered\ninsulin, compared with that reported in 5\nhealthy control horses. Pancreatic insulin secretion\nwas not insufficient in horses with lower motor\nneuron degeneration. Findings in the 2 diseased\ncontrol horses were unremarkable.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Increased\nglucose metabolism in horses with lower motor neuron\ndegeneration may be the cause of the decreased\nplasma glucose curve detected after oral glucose tolerance\ntesting. This finding could aid in developing\nsupportive treatments with respect to adequate glucose\nand vitamin E supplementation. (\n                    <jats:italic>Am J Vet Res<\/jats:italic>\n                    2005;66:271\u2013276)\n                  <\/jats:p>","DOI":"10.2460\/ajvr.2005.66.271","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T22:29:02Z","timestamp":1135204142000},"page":"271-276","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of glucose metabolism in three horses with lower motor neuron degeneration"],"prefix":"10.2460","volume":"66","author":[{"given":"Johannes H.","family":"van der Kolk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim E. P. 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Glycogen storage diseases and other inherited disorders of carbohydrate metabolism. In: Braunwald E, Fauci AS, Kasper DL, et al. 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