{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:20:47Z","timestamp":1762100447396,"version":"3.38.0"},"reference-count":34,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2005,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine whether specific treadmill\nexercise regimens would accelerate age-related\nchanges in collagen fibril diameter distributions in the\ncommon digital extensor tendon (CDET) of the forelimbs\nof young Thoroughbreds.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201424 female Thoroughbreds.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Horses were trained for 18 weeks (6\nhorses; short term) or 18 months (5 horses; long\nterm) on a high-speed treadmill; 2 age-matched control\ngroups (6 horses\/group) performed walking exercise\nonly. Horses were (mean \u00b1 SD) 24 \u00b1 1 months\nand 39 \u00b1 1 months old at termination of the shortterm\nand long-term regimens, respectively.\nMidmetacarpal CDET specimens were obtained and\nprocessed for transmission electron microscopy.\nDiameter and area of at least 1,000 collagen\nfibrils\/specimen were measured by use of computerized\nimage analysis. Mass-average diameter (MAD) of\ncollagen fibrils and collagen fibril index were calculated\nfor each horse.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Collagen fibril MAD for the older horses\nwas significantly less than that for the younger horses.\nExercise did not significantly affect fibril diameter\nor distributions in either age group, and collagen\nfibril index did not differ significantly between\ngroups.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Age-related\nreduction in collagen fibril MAD agreed with findings\nfor other tendons and species. Training did not accelerate\nage-related change in the CDET, in contrast to a\nreported decrease in collagen fibril MAD in the superficial\ndigital flexor tendon of horses trained long term.\nOur results support the concept that the functionally\ndistinct nature of the CDET and superficial digital flexor\ntendon in horses results in fundamentally different\nresponses to high-speed exercise regimens. (<jats:italic>Am J Vet Res<\/jats:italic> 2005;66:564\u2013568)<\/jats:p>","DOI":"10.2460\/ajvr.2005.66.564","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T11:51:46Z","timestamp":1135165906000},"page":"564-568","source":"Crossref","is-referenced-by-count":18,"title":["Effect of exercise on age-related changes in collagen fibril diameter distributions in the common digital extensor tendons of young horses"],"prefix":"10.2460","volume":"66","author":[{"given":"Lindsey J.","family":"Edwards","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen E.","family":"Goodship","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen L.","family":"Birch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet C.","family":"Patterson-Kane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.2746\/042516401776254808"},{"key":"p_2","first-page":"594","author":"McIlwraith CW","year":"2002","journal-title":"Philadelphia: Lippincott Williams & Wilkins"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.3109\/17453677508989277"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.2746\/042516403776148327"},{"key":"p_6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/03008207809152283","volume":"6","author":"Kastelic J","year":"1978","journal-title":"Connect Tissue Res"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00023-2"},{"key":"p_8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1098\/rspb.1978.0107","volume":"203","author":"Parry DAD","year":"1978","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"p_9","first-page":"1","author":"Parry DAD","year":"1988","journal-title":"Fla: CRC Press Inc"},{"key":"p_10","first-page":"197","author":"Torp S","year":"1975","journal-title":"London: Butterworths"},{"key":"p_11","first-page":"34","author":"Parry DAD","year":"1984","journal-title":"Boston: Martinus Nijhoff Publishing"},{"key":"p_12","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/107110079101200207","volume":"12","author":"Strocchi R","year":"1991","journal-title":"Foot Ankle"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.3109\/03008209709160225"},{"key":"p_14","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.2042-3306.1999.tb05222.x","volume":"30","author":"Birch HL","year":"1999","journal-title":"Equine Vet J Suppl"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1997.tb01653.x"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(02)00148-4"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1998.0167"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-0233(03)00141-2"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1002\/bip.1977.360160506"},{"key":"p_20","doi-asserted-by":"publisher","DOI":"10.1016\/0040-8166(92)90066-G"},{"key":"p_21","doi-asserted-by":"publisher","DOI":"10.1007\/BF00214251"},{"key":"p_22","first-page":"517","author":"Wilson AM","year":"2000","journal-title":"UK: John Wiley & Sons"},{"key":"p_24","doi-asserted-by":"publisher","DOI":"10.1053\/jvet.2002.34659"},{"key":"p_25","first-page":"655","volume":"67","author":"Sakuma K","year":"1993","journal-title":"Nippon Seikeigeka Gakkai Zasshi"},{"key":"p_26","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100010305"},{"key":"p_27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1098\/rspb.1978.0106","volume":"18","author":"Parry DAD","year":"1978","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"p_28","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00052-9"},{"key":"p_29","doi-asserted-by":"crossref","first-page":"780","DOI":"10.2106\/00004623-198163050-00013","volume":"63","author":"Woo SL","year":"1981","journal-title":"J Bone Joint Surg Am"},{"key":"p_30","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.2460\/ajvr.1993.54.11.1797","volume":"54","author":"Gillis CL","year":"1993","journal-title":"Am J Vet Res"},{"key":"p_31","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2002.tb05430.x"},{"key":"p_32","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.1.231"},{"key":"p_33","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1986.tb03659.x"},{"key":"p_34","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000126332.91435.76"},{"key":"p_35","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1999.tb03802.x"},{"key":"p_36","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.2042-3306.1999.tb05282.x","volume":"30","author":"Firth EC","year":"1999","journal-title":"Equine Vet J Suppl"}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/66\/4\/ajvr.2005.66.564.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/66\/4\/ajvr.2005.66.564.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/66\/4\/ajvr.2005.66.564.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T12:09:38Z","timestamp":1741349378000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/66\/4\/ajvr.2005.66.564.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,1]]},"references-count":34,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.2005.66.564","relation":{},"ISSN":["0002-9645"],"issn-type":[{"type":"print","value":"0002-9645"}],"subject":[],"published":{"date-parts":[[2005,4,1]]}}}