{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T19:01:13Z","timestamp":1773687673310,"version":"3.50.1"},"reference-count":28,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2005,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To assess the effect of desmopressin\n(DDAVP) administration in Doberman Pinschers with\ntype 1 von Willebrand disease (vWD) on plasma von\nWillebrand factor (vWF) multimers through determination\nof vWF collagen binding activity (vWF:CBA; a\nfunctional vWF assay dependent on the presence of\nhigh\u2013molecular-weight [HMW] multimers), comparison\nof vWF antigen concentration (vWF:Ag) to\nvWF:CBA, and vWF multimer size distribution.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201416 Doberman Pinschers with type 1 vWD\nand 5 clinically normal control dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Plasma vWF:Ag and vWF:CBA assays\nand vWF multimer analysis were performed before\nand 1 hour after administration of DDAVP (1 \u00b5g\/kg,\nSC).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Following DDAVP administration, dogs with\ntype 1 vWD had an increase in mean baseline values\nof plasma vWF:Ag and vWF:CBA from 10% to 17%\nfor both variables. The mean vWF Ag:CBA ratio at\nbaseline (0.95) was similar after DDAVP administration\n(0.97), indicating concordant increases in plasma\nvWF concentration and activity. In control dogs, mean\nplasma vWF:Ag and vWF:CBA increased from baseline\nvalues of 64% to 113% and 58% to 114%,\nrespectively, and the vWF Ag:CBA ratios were\nunchanged (1.1 vs 1.0) after DDAVP administration.\nPlasma vWF multimer analysis revealed proportional\nincreases in band intensity for all multimer sizes following\nDDAVP administration, in comparison to baseline\nfor the control dogs and Doberman Pinschers\nwith vWD, consistent with vWF Ag:CBA ratios of\napproximately 1.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Beneficial\neffects of DDAVP on primary hemostasis in\nDoberman Pinschers with type 1 vWD cannot be\nexplained by preferential increases in HMW vWF multimers.\n(<jats:italic>Am J Vet Res<\/jats:italic> 2005;66:861\u2013867)<\/jats:p>","DOI":"10.2460\/ajvr.2005.66.861","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T15:16:44Z","timestamp":1135178204000},"page":"861-867","source":"Crossref","is-referenced-by-count":20,"title":["Effect of desmopressin on von Willebrand factor multimers in Doberman Pinschers with type 1 von Willebrand disease"],"prefix":"10.2460","volume":"66","author":[{"given":"Mary Beth","family":"Callan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs","family":"Giger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James 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