{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:20:46Z","timestamp":1762100446304,"version":"3.38.0"},"reference-count":23,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2005,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To confirm whether the plasma glucose\nconcentration curve obtained during oral glucose tolerance\ntests (OGTTs) in horses with equine motor\nneuron disease (EMND) is decreased, compared with\nthat obtained in clinically normal horses, and determine\nwhether that decrease is a result of defective\nglucose metabolism or intestinal glucose transport\ndysfunction.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20148 horses with EMND and 44 matched control\nhorses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Electromyography and OGTTs were performed\nin all 8 affected horses and 10 control horses.\nIntravenous GTTs (IVGTTs) were performed in 6\naffected horses and another 11 control horses. The\nactivity and levels of jejunal luminal membrane glucose\ntransporter (Na<jats:sup>+<\/jats:sup>\/glucose cotransporter isoform 1\n[SGLT1]) were measured in 2 affected horses and 23\ncontrol horses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014In horses with EMND, generalized neuropathy\nwas detected via quantitative electromyography;\nthe mean increase in plasma glucose concentration\nduring the OGTT was significantly decreased,\ncompared with the value in control horses. During the\nIVGTT, the mean increase in plasma glucose concentration\nwas significantly lower than that of control\nhorses. The activity and levels of SGLT1 in 2 affected\nhorses were similar to those of control horses.\nDiagnosis of EMND was confirmed postmortem in all\naffected horses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Data suggest\nthat the decreased plasma glucose curve obtained in\nhorses with EMND during OGTTs (compared with\ncontrol horses) is a result of overall enhanced glucose\nmetabolism or abnormalities in the facilitated glucose\ntransporters; definitive identification of the underlying\nmechanisms could aid in the development of appropriate\ntreatments of EMND in horses. 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