{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:15:56Z","timestamp":1776132956544,"version":"3.50.1"},"reference-count":27,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To determine whether delivery of compounded liquid sildenafil directly to the stomach of dogs with megaesophagus (ME) would affect esophageal clearance, regurgitation frequency, body weight, or quality of life.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>10 client-owned otherwise healthy dogs with stable ME.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>A randomized crossover study was performed. Dogs received either sildenafil (1 mg\/kg, PO, q 12 h) or a placebo for 14 days, followed by a 7-day washout period, then the opposite treatment for 14 days. Esophageal clearance time was assessed by means of videofluoroscopy prior to treatment and on day 1 of each treatment period. Owners maintained logs of regurgitation episodes and quality of life.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Compounded liquid sildenafil moved into the stomach during 21 of 30 (70%) videofluoroscopy sessions. Sildenafil resulted in a significant reduction in the number of regurgitation episodes (median, 3.5 episodes\/wk; range, 0 to 14.5 episodes\/wk), compared with baseline (median, 6.5 episodes\/wk; range, 1.5 to 19.5 episodes\/wk) and the placebo (median, 4 episodes\/wk; range, 0 to 28 episodes\/wk), and a significant increase in body weight (median, 22.05 kg; range, 6 to 26.3 kg), compared with baseline (median, 21.55 kg; range, 5.1 to 26.2 kg) and the placebo (median, 22.9 kg; range, 5.8 to 25.9 kg). There were no differences in esophageal clearance times or quality-of life-scores between sildenafil and placebo.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Although significant differences with placebo administration were identified, clinically relevant improvements were not seen with the use of compounded liquid sildenafil in dogs with ME.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.21.02.0030","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T19:15:58Z","timestamp":1642792558000},"page":"317-323","source":"Crossref","is-referenced-by-count":10,"title":["A randomized crossover study of compounded liquid sildenafil for treatment of generalized megaesophagus in dogs"],"prefix":"10.2460","volume":"83","author":[{"given":"Susan O.","family":"Mehain","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian M.","family":"Haines","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah C.","family":"Guess","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Textbook of Veterinary Internal Medicine","first-page":"1476","article-title":"Diseases of the pharynx and esophagus","author":"Marks S","year":"2017","unstructured":"Marks S. Diseases of the pharynx and esophagus. In: Ettinger S, Feldman E, C\u00f4t\u00e9 E, eds. Textbook of Veterinary Internal Medicine. 8th ed. Elsevier; 2017:1476\u20131490."},{"issue":"5","key":"ref2","series-title":"J Am Vet Med Assoc.","first-page":"443","article-title":"Megaesophagus in the dog: a clinical survey of 79 cases","volume":"165","author":"Harvey CE","year":"1974","unstructured":"Harvey CE, O\u2019Brien JA, Durie VR, Miller DJ, Veenema R. Megaesophagus in the dog: a clinical survey of 79 cases. J Am Vet Med Assoc. 1974;165(5):443\u2013446."},{"issue":"5","key":"ref3","series-title":"Vet Clin North Am Small Anim Pract.","first-page":"1007","article-title":"Gastrointestinal motility disorders and gastrointestinal prokinetic therapy","volume":"33","author":"Washabau RJ","year":"2003","unstructured":"Washabau RJ. Gastrointestinal motility disorders and gastrointestinal prokinetic therapy. Vet Clin North Am Small Anim Pract. 2003;33(5):1007\u20131028. doi:10.1016\/S0195-5616(03)00076-7"},{"issue":"1","key":"ref4","series-title":"J Am Anim Hosp Assoc.","first-page":"33","article-title":"Megaesophagus in the dog: a review of 50 cases","volume":"21","author":"Boudrieau R","year":"1985","unstructured":"Boudrieau R, Rogers W. Megaesophagus in the dog: a review of 50 cases. J Am Anim Hosp Assoc. 1985;21(1):33\u201340."},{"key":"ref5","series-title":"Vet Med Small Anim Clin.","first-page":"37","article-title":"Clinical signs of idiopathic megaesophagus in Great Dane puppies","volume":"78","author":"Glidewell H","year":"1983","unstructured":"Glidewell H. Clinical signs of idiopathic megaesophagus in Great Dane puppies. Vet Med Small Anim Clin. 1983;78:37\u201345."},{"key":"ref6","series-title":"Strombeck\u2019s Small Animal Gastroenterology","first-page":"211","article-title":"Diseases of swallowing","author":"Guilford W","year":"1996","unstructured":"Guilford W, Strombeck D. Diseases of swallowing. In: Guilford WG, Center SA, Strombeck DR, Williams DA, Meyer DJ, eds. Strombeck\u2019s Small Animal Gastroenterology. 3rd ed. WB Saunders Co; 1996:211\u2013238."},{"issue":"12","key":"ref7","series-title":"J Am Vet Med Assoc.","first-page":"1622","article-title":"Clinical factors associated with death before discharge and overall survival time in dogs with generalized megaesophagus","volume":"238","author":"McBrearty AR","year":"2011","unstructured":"McBrearty AR, Ramsey IK, Courcier EA, Mellor DJ, Bell R. Clinical factors associated with death before discharge and overall survival time in dogs with generalized megaesophagus. J Am Vet Med Assoc. 2011;238(12):1622\u20131628. doi:10.2460\/javma.238.12.1622"},{"issue":"1","key":"ref8","series-title":"In Pract.","first-page":"14","article-title":"Management of megaoesophagus in the dog","volume":"16","author":"Simpson J","year":"1994","unstructured":"Simpson J. Management of megaoesophagus in the dog. In Pract. 1994;16(1):14\u201316. doi:10.1136\/inpract.16.1.14"},{"key":"ref9","series-title":"Orphanet J Rare Dis.","first-page":"89","article-title":"Idiopathic (primary) achalasia: a review","volume":"10","author":"Patel DA","year":"2015","unstructured":"Patel DA, Kim HP, Zifodya JS, Vaezi MF. Idiopathic (primary) achalasia: a review. Orphanet J Rare Dis. 2015;10:89. doi:10.1186\/s13023-015-0302-1"},{"issue":"2","key":"ref10","series-title":"Gastroenterology.","first-page":"253","article-title":"Effects of sildenafil on esophageal motility of patients with idiopathic achalasia","volume":"118","author":"Bortolotti M","year":"2000","unstructured":"Bortolotti M, Mari C, Lopilato C, Porrazzo G, Miglioli M. Effects of sildenafil on esophageal motility of patients with idiopathic achalasia. Gastroenterology. 2000;118(2):253\u2013257. doi:10.1016\/S0016-5085(00)70206-X"},{"issue":"11","key":"ref11","series-title":"Dig Dis Sci.","first-page":"2301","article-title":"Effects of sildenafil on esophageal motility of normal subjects","volume":"46","author":"Bortolotti M","year":"2001","unstructured":"Bortolotti M, Mari C, Giovannini M, Pinna S, Miglioli M. Effects of sildenafil on esophageal motility of normal subjects. Dig Dis Sci. 2001;46(11):2301\u20132306. doi:10.1023\/A:1012383424783"},{"issue":"9","key":"ref12","series-title":"Eur J Clin Invest.","first-page":"682","article-title":"Effect of sildenafil on hypertensive lower oesophageal sphincter","volume":"32","author":"Bortolotti M","year":"2002","unstructured":"Bortolotti M, Pandolfo N, Giovannini M, Mari M, Miglioli M. Effect of sildenafil on hypertensive lower oesophageal sphincter. Eur J Clin Invest. 2002;32(9):682\u2013685. doi:10.1046\/j.1365-2362.2002.01059.x"},{"issue":"6","key":"ref13","series-title":"Gut.","first-page":"758","article-title":"Effect of sildenafil on oesophageal motor function in healthy subjects and patients with oesophageal motor disorders","volume":"50","author":"Eherer AJ","year":"2002","unstructured":"Eherer AJ, Schwetz I, Hammer HF,  Effect of sildenafil on oesophageal motor function in healthy subjects and patients with oesophageal motor disorders. Gut. 2002;50(6):758\u2013764. doi:10.1136\/gut.50.6.758"},{"issue":"20","key":"ref14","series-title":"Life Sci.","first-page":"309","article-title":"Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum muscle cells","volume":"62","author":"Moreland RB","year":"1998","unstructured":"Moreland RB, Goldstein I, Traish A. Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum muscle cells. Life Sci. 1998;62(20):309\u2013318. doi:10.1016\/S0024-3205(98)00158-1"},{"issue":"12","key":"ref15","series-title":"Am J Gastroenterol.","first-page":"3251","article-title":"The effect of sildenafil on lower esophageal sphincter and body motility in normal male adults","volume":"96","author":"Rhee PL","year":"2001","unstructured":"Rhee PL, Hyun JG, Lee JH,  The effect of sildenafil on lower esophageal sphincter and body motility in normal male adults. Am J Gastroenterol. 2001;96(12):3251\u20133257. doi:10.1016\/S0002-9270(01)03884-9"},{"issue":"4","key":"ref16","series-title":"Neurogastroenterol Motil.","first-page":"325","article-title":"Effect of sildenafil, a phosphodiesterase-5 inhibitor, of oesophageal peristalsis and lower oesophageal sphincter function in cats","volume":"13","author":"Zhang X","year":"2001","unstructured":"Zhang X, Tack J, Janssens J, Sifrim DA. Effect of sildenafil, a phosphodiesterase-5 inhibitor, of oesophageal peristalsis and lower oesophageal sphincter function in cats. Neurogastroenterol Motil. 2001;13(4):325\u2013331. doi:10.1046\/j.1365-2982.2001.00271.x"},{"issue":"16","key":"ref17","series-title":"Vet Rec.","first-page":"404","article-title":"Sildenafil improves clinical signs and radiographic features in dogs with congenital idiopathic megaesophagus: a randomized controlled trial","volume":"180","author":"Quintavalla F","year":"2017","unstructured":"Quintavalla F, Menozzi A, Pozzoli C,  Sildenafil improves clinical signs and radiographic features in dogs with congenital idiopathic megaesophagus: a randomized controlled trial. Vet Rec. 2017;180(16):404. doi:10.1136\/vr.103832"},{"issue":"2","key":"ref18","series-title":"J Vet Intern Med.","first-page":"383","article-title":"Standardization of a videofluoroscopic swallow study protocol to investigate dysphagia in dogs","volume":"31","author":"Harris RA","year":"2017","unstructured":"Harris RA, Grobman ME, Allen MJ,  Standardization of a videofluoroscopic swallow study protocol to investigate dysphagia in dogs. J Vet Intern Med. 2017;31(2):383\u2013393. doi:10.1111\/jvim.14676"},{"issue":"3","key":"ref19","series-title":"Xenobiotica.","first-page":"297","article-title":"Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man","volume":"29","author":"Walker DK","year":"1999","unstructured":"Walker DK. Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man. Xenobiotica. 1999;29(3):297\u2013310. doi:10.1080\/004982599238687"},{"issue":"4","key":"ref20","series-title":"J Am Anim Hosp Assoc.","first-page":"167","article-title":"Technique for evaluation of gravity-assisted esophageal transit characteristics in dogs with megaesophagus","volume":"55","author":"Haines JM","year":"2019","unstructured":"Haines JM, Khoo A, Brinkman E, Thomason JM, Mackin AJ. Technique for evaluation of gravity-assisted esophageal transit characteristics in dogs with megaesophagus. J Am Anim Hosp Assoc. 2019;55(4):167\u2013177. doi:10.5326\/JAAHA-MS-6711"},{"issue":"3","key":"ref21","series-title":"J Vet Pharmacol Ther.","first-page":"457","article-title":"Pharmacokinetics of single-dose sildenafil administered orally in clinically healthy dogs: effect of feeding and dose proportionality","volume":"41","author":"Akabane R","year":"2018","unstructured":"Akabane R, Sato T, Sakatani A, Miyagawa Y, Tazaki H, Takemura N. Pharmacokinetics of single-dose sildenafil administered orally in clinically healthy dogs: effect of feeding and dose proportionality. J Vet Pharmacol Ther. 2018;41(3):457\u2013462. doi:10.1111\/jvp.12487"},{"issue":"suppl 1","key":"ref22","series-title":"Br J Clin Pharmacol.","first-page":"61S","article-title":"Onset and duration of action of sildenafil for the treatment of erectile dysfunction","volume":"53","author":"Eardley I","year":"2002","unstructured":"Eardley I, Ellis P, Boolell M, Wulff M. Onset and duration of action of sildenafil for the treatment of erectile dysfunction. Br J Clin Pharmacol. 2002;53(suppl 1):61S\u201365S. doi:10.1046\/j.0306-5251.2001.00034.x"},{"issue":"suppl 1","key":"ref23","series-title":"Br J Clin Pharmacol.","first-page":"5S","article-title":"Pharmacokinetics of sildenafil citrate after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality","volume":"53","author":"Nichols DJ","year":"2002","unstructured":"Nichols DJ, Muirhead GJ, Harness JA. Pharmacokinetics of sildenafil citrate after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality. Br J Clin Pharmacol. 2002;53(suppl 1):5S\u201312S. doi:10.1046\/j.0306-5251.2001.00027.x"},{"issue":"4","key":"ref24","series-title":"J Vet Intern Med.","first-page":"850","article-title":"Clinical efficacy of sildenafil in treatment of pulmonary arterial hypertension in dogs","volume":"24","author":"Brown AJ","year":"2010","unstructured":"Brown AJ, Davison E, Sleeper MM. Clinical efficacy of sildenafil in treatment of pulmonary arterial hypertension in dogs. J Vet Intern Med. 2010;24(4):850\u2013854. doi:10.1111\/j.1939-1676.2010.0517.x"},{"issue":"6","key":"ref25","series-title":"J Vet Intern Med.","first-page":"1258","article-title":"Sildenafil citrate therapy in 22 dogs with pulmonary hypertension","volume":"21","author":"Kellum HB","year":"2007","unstructured":"Kellum HB, Stepien RL. Sildenafil citrate therapy in 22 dogs with pulmonary hypertension. J Vet Intern Med. 2007;21(6):1258\u20131264. doi:10.1111\/j.1939-1676.2007.tb01947.x"},{"issue":"4","key":"ref26","series-title":"Am J Vet Res.","first-page":"361","article-title":"High-resolution manometric evaluation of the effects of cisapride and metoclopramide hydrochloride administered orally on lower esophageal sphincter pressure in awake dogs","volume":"75","author":"Kempf J","year":"2014","unstructured":"Kempf J, Lewis F, Reusch CE, Kook PH. High-resolution manometric evaluation of the effects of cisapride and metoclopramide hydrochloride administered orally on lower esophageal sphincter pressure in awake dogs. Am J Vet Res. 2014;75(4):361\u2013366. doi:10.2460\/ajvr.75.4.361"},{"issue":"8","key":"ref27","series-title":"Am J Vet Res.","first-page":"818","article-title":"High-resolution manometric evaluation of the effects of cisapride on the esophagus during administration of solid and liquid boluses in awake healthy dogs","volume":"77","author":"Ullal TV","year":"2016","unstructured":"Ullal TV, Kass PH, Conklin JL, Belafsky PC, Marks SL. High-resolution manometric evaluation of the effects of cisapride on the esophagus during administration of solid and liquid boluses in awake healthy dogs. Am J Vet Res. 2016;77(8):818\u2013827. doi:10.2460\/ajvr.77.8.818"}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/83\/4\/ajvr.21.02.0030.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/83\/4\/ajvr.21.02.0030.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/83\/4\/ajvr.21.02.0030.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T04:35:40Z","timestamp":1749616540000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/83\/4\/ajvr.21.02.0030.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":27,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.21.02.0030","relation":{},"ISSN":["0002-9645"],"issn-type":[{"value":"0002-9645","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,1]]}}}