{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:09:51Z","timestamp":1785409791255,"version":"3.56.0"},"reference-count":47,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To determine the pharmacokinetics and potential adverse effects of pimobendan after oral administration in New Zealand White rabbits (<jats:italic>Ocytolagus cuniculi<\/jats:italic>).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>10 adult sexually intact (5 males and 5 females) rabbits.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>2 pilot studies were performed with a pimobendan suspension or oral tablets. Eight rabbits received 7.5 mg of pimobendan (mean 2.08 mg\/kg) suspended in a critical care feeding formula. Plasma concentrations of pimobendan and O-demethylpimobendan (ODMP) were measured, and pharmacokinetic parameters were calculated for pimobendan by noncompartmental analysis. Body weight, food and water consumption, mentation, urine, and fecal output were monitored.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Mean \u00b1 SD maximum concentration following pimobendan administration was 15.7 \u00b1 7.54 ng\/mL and was detected at 2.79 \u00b1 1.25 hours. The half-life was 3.54 \u00b1 1.32 hours. Plasma concentrations of pimobendan were detectable for up to 24 hours. The active metabolite, ODMP, was detected in rabbits for 24 to 36 hours. An adverse event occurred following administration of pimobendan in tablet form in 1 pilot study, resulting in death secondary to aspiration. No other adverse events occurred.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Plasma concentrations of pimobendan were lower than previously reported for dogs and cats, despite administration of higher doses, and had longer time to maximum concentration and half-life. Based on this study, 2 mg\/kg of pimobendan in a critical care feeding formulation should maintain above a target plasma concentration for 12 to 24 hours. However, further studies evaluating multiple-dose administration as well as pharmacodynamic studies and clinical trials in rabbits with congestive heart failure are needed to determine accurate dose and frequency recommendations.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.21.03.0032","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T18:50:29Z","timestamp":1642186229000},"page":"356-363","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacokinetics of pimobendan following oral administration to New Zealand White rabbits (Oryctolagus cuniculus)"],"prefix":"10.2460","volume":"83","author":[{"given":"Sarah M.","family":"Ozawa","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raliegh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Sanchez-Migallon","family":"Guzman","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle G.","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raliegh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Acacia E.","family":"Masri","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raliegh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine T.","family":"Gunther-Harrington","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather K.","family":"Knych","sequence":"additional","affiliation":[{"name":"K. L. Maddy Equine Analytical Pharmacology Laboratory, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Ferrets, Rabbits and Rodents, Clinical Medicine and Surgery","first-page":"250","article-title":"Cardiovascular disease","author":"Orcutt C","year":"2020","unstructured":"Orcutt C, Malakoff R. Cardiovascular disease. In: Quesenberry K, Orcutt C, Mans C, Carpenter JW, eds. Ferrets, Rabbits and Rodents, Clinical Medicine and Surgery. 4th ed. Saunders; 2020:250\u2013257."},{"issue":"9-10","key":"ref2","series-title":"Wien Tierarztl Monatsschr.","first-page":"197","article-title":"Cardiac disease in pet rabbits. [German] Herzerkrankungen bei Kaninchen","volume":"101","author":"Schuhmann BHK","year":"2014","unstructured":"Schuhmann BHK. Cardiac disease in pet rabbits. [German] Herzerkrankungen bei Kaninchen. Wien Tierarztl Monatsschr. 2014;101(9-10):197\u2013205."},{"issue":"4","key":"ref3","series-title":"J Exot Pet Med.","first-page":"5","article-title":"First description of partial atrioventricular septal defect in a rabbit","volume":"27","author":"Di Girolamo N","year":"2018","unstructured":"Di Girolamo N, Palmieri C, Baron Toaldo M,  First description of partial atrioventricular septal defect in a rabbit. J Exot Pet Med. 2018;27(4):5\u20139."},{"issue":"1","key":"ref4","series-title":"J Small Anim Pract.","first-page":"46","article-title":"Congestive heart failure in two pet rabbits","volume":"52","author":"Lord B","year":"2011","unstructured":"Lord B, Devine C, Smith S. Congestive heart failure in two pet rabbits. J Small Anim Pract. 2011;52(1):46\u201350."},{"issue":"4","key":"ref5","series-title":"J Am Anim Hosp Assoc.","first-page":"e42","article-title":"Ventricular septal defect with aortic valve insufficiency in a New Zealand White rabbit","volume":"47","author":"V\u00f6r\u00f6s K","year":"2011","unstructured":"V\u00f6r\u00f6s K, Seehusen F, Hungerb\u00fchler S, Meyer-Lindenberg A, von der Hoeh N. Ventricular septal defect with aortic valve insufficiency in a New Zealand White rabbit. J Am Anim Hosp Assoc. 2011;47(4):e42\u2013e49. doi:10.5326\/jaaha-ms-5498"},{"issue":"5","key":"ref6","series-title":"J Am Vet Med Assoc.","first-page":"679","article-title":"Arteriosclerosis in a rabbit","volume":"194","author":"Shell LG","year":"1989","unstructured":"Shell LG, Saunders G. Arteriosclerosis in a rabbit. J Am Vet Med Assoc. 1989;194(5):679\u2013680."},{"issue":"6","key":"ref7","series-title":"Tier\u00e4erztliche Praxis Ausgabe K Kleintiere\/Heimtiere.","first-page":"423","article-title":"Mitral regurgitation due to papillary muscle dysfunction in a pet rabbit. A case report","volume":"33","author":"K\u00fcnzel F","year":"2005","unstructured":"K\u00fcnzel F, Kolm U, Bohler A, Url A. Mitral regurgitation due to papillary muscle dysfunction in a pet rabbit. A case report. Tier\u00e4erztliche Praxis Ausgabe K Kleintiere\/Heimtiere. 2005;33(6):423\u2013430."},{"key":"ref8","series-title":"J Vet Cardiol.","first-page":"49","article-title":"Aortocavitary fistula secondary to vegetative endocarditis in a rabbit","volume":"21","author":"Martel-Arquette A","year":"2019","unstructured":"Martel-Arquette A, Tjostheim SS, Miller J, Carlson J, Mans C. Aortocavitary fistula secondary to vegetative endocarditis in a rabbit. J Vet Cardiol. 2019;21:49\u201356."},{"issue":"24","key":"ref9","series-title":"Vet Rec.","first-page":"570","article-title":"Congestive heart failure with atrial fibrillation in a rabbit","volume":"121","author":"Martin MW","year":"1987","unstructured":"Martin MW, Darke PG, Else RW. Congestive heart failure with atrial fibrillation in a rabbit. Vet Rec. 1987;121(24):570\u2013571."},{"issue":"3","key":"ref10","series-title":"Lab Anim.","first-page":"246","article-title":"The laboratory rabbit: an animal model of atherosclerosis research","volume":"38","author":"Yanni AE","year":"2004","unstructured":"Yanni AE. The laboratory rabbit: an animal model of atherosclerosis research. Lab Anim. 2004;38(3):246\u2013256."},{"issue":"7","key":"ref11","series-title":"Antimicrob Agents Chemother.","first-page":"1921","article-title":"Comparison of a rabbit model of bacterial endocarditis and an in vitro infection model with simulated endocardial vegetations","volume":"44","author":"Hershberger E","year":"2000","unstructured":"Hershberger E, Coyle EA, Kaatz GW, Zervos MJ, Rybak MJ. Comparison of a rabbit model of bacterial endocarditis and an in vitro infection model with simulated endocardial vegetations. Antimicrob Agents Chemother. 2000;44(7):1921\u20131924."},{"issue":"1","key":"ref12","series-title":"Res Vet Sci.","first-page":"115","article-title":"Doxorubicin induced dilated cardiomyopathy in a rabbit model: an update","volume":"94","author":"Gava FN","year":"2013","unstructured":"Gava FN, Zacche E, Ortiz EM,  Doxorubicin induced dilated cardiomyopathy in a rabbit model: an update. Res Vet Sci. 2013;94(1):115\u2013121."},{"issue":"7","key":"ref13","series-title":"J Am Vet Med Assoc.","first-page":"764","article-title":"Clinical and pathological findings in rabbits (oryctolagus cuniculus) with cardiovascular disease: 59 cases (2001\u20132018)","volume":"259","author":"Ozawa S","year":"2021","unstructured":"Ozawa S, Guzman D, Keel K. Clinical and pathological findings in rabbits (oryctolagus cuniculus) with cardiovascular disease: 59 cases (2001\u20132018). J Am Vet Med Assoc. 2021;259(7):764\u2013776."},{"issue":"25","key":"ref14","series-title":"Vet Rec.","first-page":"961","article-title":"Electrocardiography of the normal domestic pet rabbit","volume":"167","author":"Lord B","year":"2010","unstructured":"Lord B, Boswood A, Petrie A. Electrocardiography of the normal domestic pet rabbit. Vet Rec. 2010;167(25):961\u2013965."},{"issue":"2","key":"ref15","series-title":"J Exot Pet Med.","first-page":"223","article-title":"Determination of normal echocardiographic, electrocardiographic, and radiographic cardiac parameters in the conscious New Zealand Wite Rabbit","volume":"24","author":"Turner Giannico A","year":"2015","unstructured":"Turner Giannico A, Ayres Garcia DA, Lima L, De Lara FA. Determination of normal echocardiographic, electrocardiographic, and radiographic cardiac parameters in the conscious New Zealand Wite Rabbit. J Exot Pet Med. 2015;24(2):223\u2013234."},{"issue":"2","key":"ref16","series-title":"Vet Anaesth Analg.","first-page":"174","article-title":"Comparison of direct and Doppler arterial blood pressure measurements in rabbits during isoflurane anaesthesia","volume":"39","author":"Harvey L","year":"2012","unstructured":"Harvey L, Knowles T, Murison PJ. Comparison of direct and Doppler arterial blood pressure measurements in rabbits during isoflurane anaesthesia. Vet Anaesth Analg. 2012;39(2):174\u2013184."},{"issue":"3","key":"ref17","series-title":"J Auton Nerv Syst.","first-page":"235","article-title":"Circadian and short-term variabilities in blood pressure and heart rate measured by telemetry in rabbits and rats","volume":"54","author":"Sato K","year":"1995","unstructured":"Sato K, Chatani F, Sato S. Circadian and short-term variabilities in blood pressure and heart rate measured by telemetry in rabbits and rats. J Auton Nerv Syst. 1995;54(3):235\u2013246."},{"issue":"4","key":"ref18","series-title":"Eur Heart J.","first-page":"551","article-title":"Calcium sensitization with pimobendan: pharmacology, haemodynamic improvement, and sudden death in patients with chronic congestive heart failure","volume":"14","author":"Hagemeijer F","year":"1993","unstructured":"Hagemeijer F. Calcium sensitization with pimobendan: pharmacology, haemodynamic improvement, and sudden death in patients with chronic congestive heart failure. Eur Heart J. 1993;14(4):551\u2013566."},{"issue":"1-2","key":"ref19","series-title":"Eur J Pharmacol.","first-page":"21","article-title":"Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties","volume":"126","author":"Verdouw PD","year":"1986","unstructured":"Verdouw PD, Hartog JM, Duncker DJ, Roth W, Saxena PR. Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties. Eur J Pharmacol. 1986;126(1-2):21\u201330."},{"issue":"3","key":"ref20","series-title":"J Pharmacol Exp Ther.","first-page":"1304","article-title":"Effects of pimobendan, a cardiotonic and vasodilating agent with phosphodiesterase inhibiting properties, on isolated arteries and veins of rats","volume":"252","author":"Fujimoto S","year":"1990","unstructured":"Fujimoto S, Matsuda T. Effects of pimobendan, a cardiotonic and vasodilating agent with phosphodiesterase inhibiting properties, on isolated arteries and veins of rats. J Pharmacol Exp Ther. 1990;252(3):1304\u2013311."},{"issue":"3","key":"ref21","series-title":"Circ Res.","first-page":"689","article-title":"Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium","volume":"68","author":"Bohm M","year":"1991","unstructured":"Bohm M, Morano I, Pieske B,  Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium. Circ Res. 1991;68(3):689\u2013701."},{"issue":"12","key":"ref22","series-title":"Circ J.","first-page":"1915","article-title":"Cardiac Ca2+ signaling and Ca2+ sensitizers","volume":"72","author":"Endoh M","year":"2008","unstructured":"Endoh M. Cardiac Ca2+ signaling and Ca2+ sensitizers. Circ J. 2008;72(12):1915\u20131925."},{"issue":"6","key":"ref23","series-title":"J Vet Intern Med.","first-page":"1142","article-title":"Guidelines for the diagnosis and treatment of canine chronic valvular heart disease","volume":"23","author":"Atkins C","year":"2009","unstructured":"Atkins C, Bonagura J, Ettinger S,  Guidelines for the diagnosis and treatment of canine chronic valvular heart disease. J Vet Intern Med. 2009;23(6):1142\u20131150."},{"issue":"6","key":"ref24","series-title":"J Vet Intern Med.","first-page":"1337","article-title":"Efficacy of pimobendan in the prevention of congestive heart failure or sudden death in Doberman Pinschers with preclinical dilated cardiomyopathy (the PROTECT Study)","volume":"26","author":"Summerfield NJ","year":"2012","unstructured":"Summerfield NJ, Boswood A, O\u2019Grady MR,  Efficacy of pimobendan in the prevention of congestive heart failure or sudden death in Doberman Pinschers with preclinical dilated cardiomyopathy (the PROTECT Study). J Vet Intern Med. 2012;26(6):1337\u20131349."},{"issue":"6","key":"ref25","series-title":"J Vet Intern Med.","first-page":"1765","article-title":"Effect of pimobendan in dogs with preclinical myxomatous mitral valve disease and cardiomegaly: the epic study\u2014a randomized clinical trial","volume":"30","author":"Boswood A","year":"2016","unstructured":"Boswood A, Haggstrom J, Gordon SG,  Effect of pimobendan in dogs with preclinical myxomatous mitral valve disease and cardiomegaly: the epic study\u2014a randomized clinical trial. J Vet Intern Med. 2016;30(6):1765\u20131779."},{"issue":"2","key":"ref26","series-title":"J Vet Intern Med.","first-page":"553","article-title":"Long-term outcome of irish wolfhound dogs with preclinical cardiomyopathy, atrial fibrillation, or both treated with pimobendan, benazepril hydrochloride, or methyldigoxin monotherapy","volume":"30","author":"Vollmar AC","year":"2016","unstructured":"Vollmar AC, Fox PR. Long-term outcome of irish wolfhound dogs with preclinical cardiomyopathy, atrial fibrillation, or both treated with pimobendan, benazepril hydrochloride, or methyldigoxin monotherapy. J Vet Intern Med. 2016;30(2):553\u2013559."},{"issue":"1","key":"ref27","series-title":"J Vet Intern Med.","first-page":"72","article-title":"Longitudinal analysis of quality of life, clinical, radiographic, echocardiographic, and laboratory variables in dogs with preclinical myxomatous mitral valve disease receiving pimobendan or placebo: the EPIC study","volume":"32","author":"Boswood A","year":"2018","unstructured":"Boswood A, Gordon SG, H\u00e4ggstr\u00f6m J,  Longitudinal analysis of quality of life, clinical, radiographic, echocardiographic, and laboratory variables in dogs with preclinical myxomatous mitral valve disease receiving pimobendan or placebo: the EPIC study. J Vet Intern Med. 2018;32(1):72\u201385."},{"issue":"5","key":"ref28","series-title":"J Am Vet Med Assoc.","first-page":"534","article-title":"Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure","volume":"245","author":"Reina-Doreste Y","year":"2014","unstructured":"Reina-Doreste Y, Stern JA, Keene BW,  Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure. J Am Vet Med Assoc. 2014;245(5):534\u2013539."},{"issue":"2","key":"ref29","series-title":"J Med Ultraon (2001).","first-page":"173","article-title":"Pimobendan improves right ventricular myocardial contraction and attenuates pulmonary arterial hypertension in rats with monocrotaline-induced pulmonary arterial hypertension","volume":"41","author":"Yoshiyuki R","year":"2014","unstructured":"Yoshiyuki R, Nakata TM, Fukayama T,  Pimobendan improves right ventricular myocardial contraction and attenuates pulmonary arterial hypertension in rats with monocrotaline-induced pulmonary arterial hypertension. J Med Ultraon (2001). 2014;41(2):173\u2013180."},{"issue":"3","key":"ref30","series-title":"Equine Vet J.","first-page":"352","article-title":"Cardiovascular effects of pimobendan in healthy mature horses","volume":"48","author":"Afonso T","year":"2016","unstructured":"Afonso T, Gigu\u00e9re S, Rapoport G, Barton MH, Coleman AE. Cardiovascular effects of pimobendan in healthy mature horses. Equine Vet J. 2016;48(3):352\u2013356."},{"key":"ref31","series-title":"Exotic Animal Formulary","first-page":"494","article-title":"Rabbits","author":"Fisher P","year":"2018","unstructured":"Fisher P, Graham J. Rabbits. In: Carpenter J, ed. Exotic Animal Formulary. 5th ed. Elsevier; 2018:494\u2013531."},{"issue":"1","key":"ref32","series-title":"J Vet Pharmacol Ther.","first-page":"54","article-title":"The pharmacokinetics of pimobendan enantiomers after oral and intravenous administration of racemate pimobendan formulations in healthy dogs","volume":"39","author":"Bell ET","year":"2016","unstructured":"Bell ET, Devi JL, Chiu S, Zahra P, Whittem T. The pharmacokinetics of pimobendan enantiomers after oral and intravenous administration of racemate pimobendan formulations in healthy dogs. J Vet Pharmacol Ther. 2016;39(1):54\u201361."},{"issue":"4","key":"ref33","series-title":"J Vet Cardiol.","first-page":"310","article-title":"Single-dose pharmacokinetics and cardiovascular effects of oral pimobendan in healthy cats","volume":"18","author":"Yata M","year":"2016","unstructured":"Yata M, McLachlan AJ, Foster DJ, Hanzlicek AS, Beijerink NJ. Single-dose pharmacokinetics and cardiovascular effects of oral pimobendan in healthy cats. J Vet Cardiol. 2016;18(4):310\u2013325."},{"issue":"1","key":"ref34","series-title":"J Vet Pharmacol Ther.","first-page":"45","article-title":"Pharmacokinetics and cardiovascular effects following a single oral administration of a nonaqueous pimobendan solution in healthy dogs","volume":"39","author":"Yata M","year":"2016","unstructured":"Yata M, McLachlan AJ, Foster DJ, Page SW, Beijerink NJ. Pharmacokinetics and cardiovascular effects following a single oral administration of a nonaqueous pimobendan solution in healthy dogs. J Vet Pharmacol Ther. 2016;39(1):45\u201353."},{"issue":"4","key":"ref35","series-title":"J Vet Cardiol.","first-page":"489","article-title":"Pharmacokinetics of oral pimobendan in healthy cats","volume":"14","author":"Hanzlicek AS","year":"2012","unstructured":"Hanzlicek AS, Gehring R, KuKanich B,  Pharmacokinetics of oral pimobendan in healthy cats. J Vet Cardiol. 2012;14(4):489\u2013496."},{"key":"ref36","series-title":"1Vetmedin (Pimobendan) Chewable Tablets Package Insert","year":"2012","unstructured":"1Vetmedin (Pimobendan) Chewable Tablets Package Insert. Boehringer Ingelheim; 2012."},{"issue":"6","key":"ref37","series-title":"Clin Pharmacol Ther.","first-page":"610","article-title":"Pharmacokinetics and pharmacodynamics of enantiomers of pimobendan in patients with dilated cardiomyopathy and congestive heart failure after single and repeated oral dosing","volume":"57","author":"Chu K-M","year":"1995","unstructured":"Chu K-M, Shieh S-M, Hu OY-P. Pharmacokinetics and pharmacodynamics of enantiomers of pimobendan in patients with dilated cardiomyopathy and congestive heart failure after single and repeated oral dosing. Clin Pharmacol Ther. 1995;57(6):610\u2013621."},{"issue":"6","key":"ref38","series-title":"Drug Metab Dispos.","first-page":"701","article-title":"Cardiovascular effect and simultaneous pharmacokinetic and pharmacodynamic modeling of pimobendan in healthy normal subjects","volume":"27","author":"Chu K-M","year":"1999","unstructured":"Chu K-M, Hu OY-P, Shieh S-M. Cardiovascular effect and simultaneous pharmacokinetic and pharmacodynamic modeling of pimobendan in healthy normal subjects. Drug Metab Dispos. 1999;27(6):701\u2013709."},{"key":"ref39","series-title":"Boehringer Ingelheim Vetmedica I. Freedom of Information Summary: Vetmedin. NADA 141\u2013273","year":"2007","unstructured":"Boehringer Ingelheim Vetmedica I. Freedom of Information Summary: Vetmedin. NADA 141\u2013273. 2007."},{"key":"ref40","series-title":"Rabbits and Rodents, Clinical Medicine and Surgery","first-page":"162","article-title":"Gastrointestinal physiology and nutrition","author":"Smith SM","year":"2020","unstructured":"Smith SM. Gastrointestinal physiology and nutrition. In: Quesenberry KE, Carpenter JW, Christoph M, eds. Rabbits and Rodents, Clinical Medicine and Surgery. 4th eds. Saunders; 2020:162\u2013173."},{"issue":"1","key":"ref41","series-title":"Comp Med.","first-page":"63","article-title":"Pharmacokinetics of meloxicam in rabbits after single and repeat oral dosing","volume":"56","author":"Turner PV","year":"2006","unstructured":"Turner PV, Chen CH, Taylor MW. Pharmacokinetics of meloxicam in rabbits after single and repeat oral dosing. Comp Med. 2006;56(1):63\u201367."},{"issue":"5","key":"ref42","series-title":"Biopharm Drug Dispos.","first-page":"351","article-title":"Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals","volume":"16","author":"Kararli TT","year":"1995","unstructured":"Kararli TT. Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharm Drug Dispos. 1995;16(5):351\u2013380."},{"issue":"2","key":"ref43","series-title":"J Avian Med Surg.","first-page":"95","article-title":"Pharmacokinetics of single oral dose of pimobendan in Hispaniolan Amazon parrots (Amazona ventralis)","volume":"28","author":"Guzman DS","year":"2014","unstructured":"Guzman DS, Beaufrere H, KuKanich B,  Pharmacokinetics of single oral dose of pimobendan in Hispaniolan Amazon parrots (Amazona ventralis). J Avian Med Surg. 2014;28(2):95\u2013101."},{"issue":"4","key":"ref44","series-title":"J Am Anim Hosp Assoc.","first-page":"250","article-title":"Clinical signs of cardiovascular effects secondary to suspected pimobendan toxicosis in five dogs","volume":"48","author":"Reinker LN","year":"2012","unstructured":"Reinker LN, Lee JA, Hovda LR, Rishniw M. Clinical signs of cardiovascular effects secondary to suspected pimobendan toxicosis in five dogs. J Am Anim Hosp Assoc. 2012;48(4):250\u2013255."},{"issue":"3","key":"ref45","series-title":"J Pharmacol Exp Ther.","first-page":"929","article-title":"Cardiac electrophysiologic and hemodynamic activity of pimobendan (UD-CG 115 BS), a new inotropic agent","volume":"244","author":"Kitzen JM","year":"1988","unstructured":"Kitzen JM, Lynch JJ, Driscoll EM, Lucchesi BR. Cardiac electrophysiologic and hemodynamic activity of pimobendan (UD-CG 115 BS), a new inotropic agent. J Pharmacol Exp Ther. 1988;244(3):929\u2013939."},{"issue":"4","key":"ref46","series-title":"Clin Liver Dis.","first-page":"947","article-title":"The liver in heart failure","volume":"6","author":"Giallourakis CC","year":"2002","unstructured":"Giallourakis CC, Rosenberg PM, Friedman LS. The liver in heart failure. Clin Liver Dis. 2002;6(4):947\u2013967."},{"issue":"2","key":"ref47","series-title":"Clin Pharmacokinet.","first-page":"94","article-title":"Clinical pharmacokinetics in heart failure. An updated review","volume":"15","author":"Shammas FV","year":"1988","unstructured":"Shammas FV, Dickstein K. Clinical pharmacokinetics in heart failure. An updated review. Clin Pharmacokinet. 1988;15(2):94\u2013113."}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/83\/4\/ajvr.21.03.0032.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/83\/4\/ajvr.21.03.0032.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/83\/4\/ajvr.21.03.0032.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T04:35:46Z","timestamp":1749616546000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/83\/4\/ajvr.21.03.0032.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":47,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.21.03.0032","relation":{},"ISSN":["0002-9645"],"issn-type":[{"value":"0002-9645","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4,1]]}}}