{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T05:24:33Z","timestamp":1741411473133,"version":"3.38.0"},"reference-count":22,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To assess whether hyperinoculation of cats with a feline herpesvirus-1, calicivirus, and panleukopenia virus (FVRCP) vaccine could be used as a model to study interstitial nephritis and to assess humoral and cell-mediated immune responses toward vaccinal \u03b1-enolase.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>6 healthy young adult purpose-bred research cats.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Baseline renal cortical biopsies, whole blood, serum, and urine were collected prior to administration of a commercial FVRCP parenteral vaccine. Vaccine hyperinoculation was defined as a total of 8 vaccinations given at 2-week intervals over a 14-week period. Blood samples were collected immediately prior to each vaccination, and a second renal biopsy was performed 2 weeks after hyperinoculation (week 16). Renal histopathology, renal \u03b1-enolase immunohistochemistry, and assays to detect humoral and cell-mediated immune reactions against Crandell-Rees feline kidney (CRFK) cell lysates and \u03b1-enolase were performed. An \u03b1-enolase immunoreactivity score for renal tubules and glomeruli based on signal intensity was determined by a blinded pathologist.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Hyperinoculation with the vaccine was not associated with clinicopathologic evidence of renal dysfunction, and interstitial nephritis was not recognized by light microscopy in the time studied. The mean serum absorbance values for antibodies against CRFK antigen and \u03b1-enolase were significantly (<jats:italic>P<\/jats:italic> &lt; 0.001) higher at weeks 4, 8, and 16 versus week 0. Renal tubular and glomerular \u03b1-enolase immunoreactivity scores were higher at week 16 compared to baseline.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Findings suggested that systemic immunological reactions occurred and renal tissues were affected by vaccine hyperinoculation; however, short-term FVRCP vaccine hyperinoculation cannot be used to study interstitial nephritis in cats.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.21.07.0087","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T13:02:09Z","timestamp":1654088529000},"source":"Crossref","is-referenced-by-count":1,"title":["Effect of repeated administration of a parenteral feline herpesvirus-1, calicivirus, and panleukopenia virus vaccine on select clinicopathologic, immunological, renal histologic, and immunohistochemical parameters in healthy adult cats"],"prefix":"10.2460","volume":"83","author":[{"given":"Stacie C.","family":"Summers","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon M.","family":"McLeland","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer R.","family":"Hawley","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica M.","family":"Quimby","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Lappin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"B1","series-title":"J Feline Med Surg","first-page":"465","article-title":"Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies","volume":"16","year":"2014","unstructured":"Marino CL, Lascelles BD, Vaden SL, Gruen ME, Marks SL. Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies. J Feline Med Surg. 2014;16:465\u2013472.24217707"},{"issue":"3","key":"B2","series-title":"Vet Pathol","first-page":"524","article-title":"A comparison of biochemical and histopathologic staging in cats with chronic kidney disease","volume":"52","year":"2015","unstructured":"McLeland SM, Cianciolo RE, Duncan CG, Quimby JM. A comparison of biochemical and histopathologic staging in cats with chronic kidney disease. Vet Pathol. 2015;52(3):524\u2013534.25516066"},{"issue":"2","key":"B3","series-title":"Vet Pathol","first-page":"309","article-title":"Chronic kidney disease in aged cats: clinical features, morphology, and proposed pathogeneses","volume":"53","year":"2016","unstructured":"Brown CA, Elliott J, Schmiedt CW, Brown SA. Chronic kidney disease in aged cats: clinical features, morphology, and proposed pathogeneses. Vet Pathol. 2016;53(2):309\u2013326.26869151"},{"issue":"3","key":"B4","series-title":"J Am Vet Med Assoc","first-page":"320","article-title":"Risk factors associated with the development of chronic kidney disease in cats evaluated at primary care veterinary hospitals","volume":"244","year":"2014","unstructured":"Greene JP, Lefebvre SL, Wang M, Yang M, Lund EM, Polzin DJ. Risk factors associated with the development of chronic kidney disease in cats evaluated at primary care veterinary hospitals. J Am Vet Med Assoc. 2014;244(3):320\u2013327.24432964"},{"issue":"2","key":"B5","series-title":"J Vet Intern Med","first-page":"602","article-title":"Risk factors for development of chronic kidney disease in cats","volume":"30","year":"2016","unstructured":"Finch NC, Syme HM, Elliott J. Risk factors for development of chronic kidney disease in cats. J Vet Intern Med. 2016;30(2):602\u2013610.26948860"},{"issue":"9","key":"B6","series-title":"J Feline Med Surg","first-page":"813","article-title":"2020 AAHA\/AAFP Feline Vaccination Guidelines","volume":"22","year":"2020","unstructured":"Stone AE, Brummet GO, Carozza EM, Lappin MR. 2020 AAHA\/AAFP Feline Vaccination Guidelines. J Feline Med Surg. 2020;22(9):813\u2013830.32845224"},{"issue":"3","key":"B7","series-title":"In Vitro","first-page":"176","article-title":"Development, characterization, and viral susceptibility of a feline (Felis catus) renal cell line (CRFK)","volume":"9","year":"1973","unstructured":"Crandell RA, Fabricant CG, Nelson-Rees WA. Development, characterization, and viral susceptibility of a feline (Felis catus) renal cell line (CRFK). In Vitro. 1973;9(3):176\u2013185.4130570"},{"issue":"3","key":"B8","series-title":"Am J Vet Res","first-page":"506","article-title":"Investigation of the induction of antibodies against Crandell-Rees feline kidney cell lysates and feline renal cell lysates after parenteral administration of vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia in cats","volume":"66","year":"2005","unstructured":"Lappin MR, Jensen WA, Jensen TD, et al. Investigation of the induction of antibodies against Crandell-Rees feline kidney cell lysates and feline renal cell lysates after parenteral administration of vaccines against feline viral rhinotracheitis, calicivirus, and panleukopenia in cats. Am J Vet Res. 2005;66(3):506\u2013511.15822597"},{"issue":"2","key":"B9","series-title":"J Vet Intern Med","first-page":"306","article-title":"Antibodies against Crandell Rees Feline Kidney (CRFK) cell line antigens, \u03b1-enolase, and annexin A2 in vaccinated and CRFK hyperinoculated cats","volume":"24","year":"2010","unstructured":"Whittemore JC, Hawley JR, Jensen WA, et al. Antibodies against Crandell Rees Feline Kidney (CRFK) cell line antigens, \u03b1-enolase, and annexin A2 in vaccinated and CRFK hyperinoculated cats. J Vet Intern Med. 2010;24(2):306\u2013313.20136712"},{"issue":"5","key":"B10","series-title":"J Feline Med Surg","first-page":"353","article-title":"Interstitial nephritis in cats inoculated with Crandell Rees feline kidney cell lysates","volume":"8","year":"2006","unstructured":"Lappin M, Basaraba R, Jensen W. Interstitial nephritis in cats inoculated with Crandell Rees feline kidney cell lysates. J Feline Med Surg. 2006;8(5):353\u2013356.16713319"},{"issue":"3","key":"B11","series-title":"Am J Pathol","first-page":"488","article-title":"Enolase isozymes in renal tubules and renal cell carcinoma","volume":"124","year":"1986","unstructured":"Haimoto H, Takashi M, Koshikawa T, Asai J, Kato K. Enolase isozymes in renal tubules and renal cell carcinoma. Am J Pathol. 1986;124(3):488\u2013495.3766707"},{"issue":"12","key":"B12","series-title":"Eur J Immunol","first-page":"3575","article-title":"Surface expression of a glycolytic enzyme, alpha-enolase, recognized by autoantibodies in connective tissue disorders","volume":"30","year":"2000","unstructured":"Moscato S, Pratesi F, Sabbatini A, et al. Surface expression of a glycolytic enzyme, alpha-enolase, recognized by autoantibodies in connective tissue disorders. Eur J Immunol. 2000;30(12):3575\u20133584.11169399"},{"key":"B13","series-title":"Vet Immunol Immunopath","first-page":"23","article-title":"Alpha-enolase staining patterns in the renal tissues of cats with and without chronic kidney disease","volume":"212","year":"2019","unstructured":"McLeland S, Quimby J, Lappin MR. Alpha-enolase staining patterns in the renal tissues of cats with and without chronic kidney disease. Vet Immunol Immunopath. 2019;212:23\u201326."},{"key":"B14","series-title":"J Feline Med Surg","first-page":"824","article-title":"Effect of modified live or inactivated feline herpesvirus-1 parenteral vaccines on clinical and laboratory findings following viral challenge","volume":"19","year":"2017","unstructured":"Summers SC, Ruch-Gallie R, Hawley JR, Lappin MR. Effect of modified live or inactivated feline herpesvirus-1 parenteral vaccines on clinical and laboratory findings following viral challenge. 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J Investig Med. 2001;49(2):138\u2013145."},{"key":"B17","series-title":"J Clin Immunol","first-page":"181","article-title":"The role of anti-alpha-enolase autoantibodies in pathogenicity of autoimmune-mediated retinopathy","volume":"27","year":"2007","unstructured":"Magrys A, Anekonda T, Ren G, et al. The role of anti-alpha-enolase autoantibodies in pathogenicity of autoimmune-mediated retinopathy. J Clin Immunol. 2007;27:181\u2013192.17235687"},{"issue":"1","key":"B18","series-title":"J Rheumatol","first-page":"109","article-title":"Autoantibodies specific for alpha-enolase in systemic autoimmune disorders","volume":"27","year":"2000","unstructured":"Pratesi F, Moscato S, Sabbatini A, Adamus G. Autoantibodies specific for alpha-enolase in systemic autoimmune disorders. 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Circulating antibodies to \u03b1-enolase and phospholipase A(2) receptor and composition of glomerular deposits in Japanese patients with primary or secondary membranous nephropathy. Clin Exp Nephrol. 2017;21:117\u2013126."},{"key":"B21","series-title":"Autoimmun Rev","first-page":"168","article-title":"The targets of nephritogenic antibodies in systemic autoimmune disorders","volume":"1","year":"2002","unstructured":"Migliorini P, Pratesi F, Bongiorni F, Moscato S, Scavuzzo M, Bombardieri S. The targets of nephritogenic antibodies in systemic autoimmune disorders. Autoimmun Rev. 2002;1:168\u2013173.12849011"},{"key":"B22","series-title":"Lupus","first-page":"139","article-title":"Serum level of anti-alpha-enolase antibody in untreated systemic lupus erythematosus patients correlates with 24-hour urine protein and D-dimer","volume":"27","year":"2018","unstructured":"Li M, Li J, Wang J, Li Y, Yang P. 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