{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:55:39Z","timestamp":1791284139173,"version":"4.1.0"},"reference-count":35,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate the agreement between 3 point-of-care (POC) devices and a reference laboratory for measuring \u03b2-hydroxybutyrate (\u03b2-HB) concentration in African penguin (<jats:italic>Spheniscus demersus<\/jats:italic>) whole blood (WB) and plasma samples and the precision of each POC device for measuring \u03b2-HB concentration in plasma samples.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>48 healthy African penguins.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Blood was obtained from the right jugular vein of each penguin, and \u03b2-HB concentration was measured on each POC device using fresh WB and heparinized plasma and at the reference laboratory using plasma. \u03b2-HB concentration was measured in plasma on each POC device.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>All devices overestimated serum \u03b2-HB concentrations on average by 0.46 mM relative to the reference laboratory. WB samples had less error than plasma for meters A and C. Meter A had the lowest total error observed (26.4%) and the lowest mean difference (0.19 mmol\/L) relative to the reference laboratory. Controlling for other factors, the magnitude of disagreement was not affected by sex, age, packed cell volume, or serum total solids concentration.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>WB, not plasma, should be used for measurement of \u03b2-HB concentration on the POC meters tested. Meter A showed good correlation with the reference laboratory for WB. The use of POC devices for the measurement of \u03b2-HB concentration may be acceptable when laboratory analyzers are not available. Further research is needed for clinical application and the diagnostic value of POC meters compared with reference laboratories.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.21.11.0192","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T12:26:18Z","timestamp":1652271978000},"source":"Crossref","is-referenced-by-count":5,"title":["Point-of-care ketone meters may be used to estimate serum \u03b2-hydroxybutyrate concentrations in healthy African penguins (Spheniscus demersus)"],"prefix":"10.2460","volume":"83","author":[{"given":"Sharonda M.","family":"Meade","sequence":"first","affiliation":[{"name":"Animal and Bird Health Care Center, Cherry Hill, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Di Girolamo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Cray","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Miami, Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette","family":"Aquilino","sequence":"additional","affiliation":[{"name":"Adventure Aquarium, Camden, NJ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"DiGeronimo","sequence":"additional","affiliation":[{"name":"Adventure Aquarium, Camden, NJ"},{"name":"Philadelphia Zoo, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"6","key":"B1","series-title":"Experientia","first-page":"575","article-title":"The biochemistry of natural fasting at its limits","volume":"48","year":"1992","unstructured":"Castellini MA, Rea LD. 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