{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:56:56Z","timestamp":1768625816139,"version":"3.49.0"},"reference-count":32,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2022,5,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate the effect of 6% hydroxyethyl starch (HES) 670\/0.75 and 6% HES 130\/0.4 dilution of canine whole blood on coagulation using dynamic viscoelastic coagulometry (DVC).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>56 healthy adult dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>2 blood samples were obtained from each dog and randomized to 1 of 7 groups\u2014undiluted or 2 dilutions (1:3 or 1:10) of 3 different fluids: saline (0.9% NaCl) solution, 6% HES 670\/0.75, or 6% HES 130\/0.4. Dilutions were calculated to simulate approximately a 10- or 30-mL\/kg body weight IV bolus of each fluid. DVC was performed on each sample. Coagulation parameters compared between groups included clot rate (CR), platelet function (PF), and activated clotting time.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Dilution with saline solution did not significantly affect coagulation, while dilution with HES 670\/0.75 and HES 130\/0.4 caused a dose-dependent significant decrease in CR (1:3 HES 670\/0.75, <jats:italic>P<\/jats:italic> = 0.007; 1:10 HES 670\/0.75, <jats:italic>P<\/jats:italic> = 0.002; 1:3 HES130\/0.4, <jats:italic>P<\/jats:italic> &lt; 0.0001; and 1:10 HES 130\/0.4, <jats:italic>P<\/jats:italic> = 0.0003) and PF (1:3 HES 670\/0.75, <jats:italic>P<\/jats:italic> &lt; 0.0001; 1:10 HES 670\/0.75, <jats:italic>P<\/jats:italic> &lt; 0.0001; 1:3 HES130\/0.4, <jats:italic>P<\/jats:italic> &lt; 0.0001; and 1:10 HES 130\/0.4, <jats:italic>P<\/jats:italic> = 0.0015).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Dilution of canine blood with HES 670\/0.75 and HES 130\/0.4, at clinically relevant doses (10 and 30 mL\/kg), led to significant hypocoagulability beyond dilutional effect. This was, in part, due to impaired PF, which was significantly greater with HES 670\/0.75. Further research using DVC to assess the effects of HES on coagulation in dogs, ideally with clinical conditions warranting HES administration, is needed.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.21.12.0203","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T19:16:56Z","timestamp":1651864616000},"source":"Crossref","is-referenced-by-count":2,"title":["In vitro effect of hydroxyethyl starch on coagulation in dogs as assessed by dynamic viscoelastic coagulometry"],"prefix":"10.2460","volume":"83","author":[{"given":"Keith A.","family":"Jarrett","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Oklahoma State University, Stillwater, OK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle R.","family":"Dugat","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Oklahoma State University, Stillwater, OK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S.","family":"Hanzlicek","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Oklahoma State University, Stillwater, OK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Payton","sequence":"additional","affiliation":[{"name":"Department of Statistics, Oklahoma State University, Stillwater, OK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"6","key":"B1","series-title":"J Vet Emerg Crit Care","first-page":"640","article-title":"In vitro evaluation of canine hemostasis following dilution with hydroxyethyl starch (130\/0.4) via thromboelastometry","volume":"22","year":"2012","unstructured":"Falco S, Bruno B, Maurella C, et al. 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