{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:10:35Z","timestamp":1761491435727,"version":"3.38.0"},"reference-count":36,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate pneumoperitoneal volumes (laparoscopic working space) in guinea pigs (<jats:italic>Cavia porcellus<\/jats:italic>) undergoing pneumoperitoneum via carbon dioxide insufflation at different intra-abdominal pressures (IAPs) (4, 6, and 8 mm Hg) and recumbencies (dorsal, right lateral, and left lateral).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>Six 3- to 4-month-old sexually intact female Hartley guinea pigs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Guinea pigs were anesthetized, intubated, and had an abdominal insufflation catheter placed. A baseline abdominal CT scan was performed. Guinea pigs underwent insufflation, with each IAP given in a random order for 10 to 15 minutes with a washout period of 5 minutes between pressures. Abdominal CT scans were acquired at each IAP and at each recumbency. Pneumoperitoneal volumes were calculated using software.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Increases in IAP increased working space significantly (<jats:italic>P<\/jats:italic> &lt; .001). The 6- and 8-mm Hg pressures increased working space from 4 mm Hg by 7.3% and 19.8%, respectively. Recumbent positioning (<jats:italic>P<\/jats:italic> = .60) and body weight (<jats:italic>P<\/jats:italic> = .73) did not affect working space. Order of IAP had a significant (<jats:italic>P<\/jats:italic> = .006) effect on working space. One of the guinea pigs experienced oxygen desaturation and bradycardia at 6- and 8-mm Hg IAP.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Although an increased working space occurred at 6 and 8 mm Hg compared to 4 mm Hg, further research is needed concerning the cardiovascular effects of pneumoperitoneum in guinea pigs to determine whether those higher IAPs are safe in this species. An IAP of 6 mm Hg can be considered for laparoscopic cannula placement, followed by a lower IAP for laparoscopic procedures.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.22.03.0031","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T12:30:35Z","timestamp":1657542635000},"source":"Crossref","is-referenced-by-count":1,"title":["Assessment of laparoscopic working space in guinea pigs (Cavia porcellus) undergoing carbon dioxide insufflation at different intra-abdominal pressures"],"prefix":"10.2460","volume":"83","author":[{"given":"Julianne E.","family":"McCready","sequence":"first","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex R.","family":"zur Linden","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugues H.","family":"Beaufr\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"1","key":"B1","series-title":"J Exot Pet Med","first-page":"21","article-title":"Single port laparoscopic-assisted ovariohysterectomy in 3 rabbits","volume":"27","year":"2018","unstructured":"Coleman KA, Monnet E, Johnston MS. 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