{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:16:14Z","timestamp":1784128574346,"version":"3.55.0"},"reference-count":51,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To assess whether cardiac MRI or various biomarkers can be used to detect myocardial ischemia and fibrosis in dogs with cardiomegaly secondary to myxomatous mitral valve disease (MMVD).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>6 dogs with cardiomegaly secondary to naturally occurring stage B2 MMVD being treated only with pimobendan with or without enalapril and 6 control dogs with no cardiac disease. All dogs were \u2265 5 years old with no systemic illness.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Serum cardiac troponin I and concentrations were measured, and dogs were anesthetized for cardiac MRI with ECG-triggered acquisition of native T1- and T2-weighted images. Gadolinium contrast was administered to evaluate myocardial perfusion and late gadolinium enhancement (LGE). Mean T1 and T2 values and regions of LGE were measured with dedicated software. Extracellular volume (ECV) was estimated on the basis of Hct and T1 values of myocardium and surrounding blood. Subjective analysis for myocardial perfusion deficits was performed.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Dogs with MMVD had significantly (<jats:italic>P<\/jats:italic> = .013) higher cardiac troponin I concentrations than control dogs, but galectin-3 concentrations did not differ (<jats:italic>P<\/jats:italic> = .08) between groups. Myocardial fibrosis was detected in 4 dogs with MMVD and 3 control dogs; no dogs had obvious myocardial perfusion deficits. Native T1 and T2 values, postcontrast T1 values, and ECV values were not significantly different between groups (all <jats:italic>P<\/jats:italic> &gt; .3).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Results suggest that some dogs with cardiomegaly secondary to MMVD may not have clinically relevant myocardial fibrosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.22.05.0076","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T18:35:14Z","timestamp":1659033314000},"source":"Crossref","is-referenced-by-count":8,"title":["Utility of cardiac MRI to diagnose myocardial ischemia and fibrosis in dogs with cardiomegaly secondary to myxomatous mitral valve disease"],"prefix":"10.2460","volume":"83","author":[{"given":"William A.","family":"Clark","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randolph L.","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH"},{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turi K.","family":"Aarnes","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Mikrut","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Ruz","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Addison","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaylyn D.","family":"Rhinehart","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten E.","family":"Schober","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry T.","family":"Friel","sequence":"additional","affiliation":[{"name":"Philips Medical Systems, Highland Heights, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"B1","series-title":"J Vet Intern Med","first-page":"1127","article-title":"ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs","volume":"33","year":"2019","unstructured":"Keene BW, Atkins CE, Bonagura JD, et al. 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