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Dogs were randomized to receive diltiazem (loading dose of 240 \u03bcg\/kg, IV followed by a CRI of 6 \u03bcg\/kg\/min for 300 minutes) or the same volume of 5% dextrose in water (D5W) administered IV followed by the opposite intervention after a 7-day washout. Blood pressure was monitored during each CRI, and echocardiographic and electrocardiographic studies were performed immediately before the CRI and during the last hour of the CRI.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Postdiltiazem systolic time interval (STI) (median, 0.30; range, 0.16 to 0.34) was significantly lower than post-D5W STI (median, 0.32; range, 0.22 to 0.40; <jats:italic>P<\/jats:italic> = .046). All other echocardiographic parameters did not differ significantly between each of the groups after receiving diltiazem or D5W. Systemic blood pressure did not change significantly with either diltiazem (<jats:italic>P<\/jats:italic> = .450) or D5W (<jats:italic>P<\/jats:italic> = .940), and none of the dogs became hypotensive at any point in the study. Expectedly, negative dromotropy was observed with diltiazem.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>A significant decrease in left ventricular systolic function was not appreciated in healthy dogs receiving diltiazem at a clinically accepted intravenous infusion rate at this dosing regimen. Further studies are needed in dogs with cardiac disease.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.22.09.0158","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T13:12:23Z","timestamp":1673010743000},"page":"1-8","source":"Crossref","is-referenced-by-count":1,"title":["A clinically utilized intravenous continuous rate infusion of diltiazem does not significantly decrease systolic function in healthy dogs"],"prefix":"10.2460","author":[{"given":"William H.","family":"Whitehouse","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin D.","family":"Thomason","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy A.","family":"Thompson-Butler","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan D.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Cernicchiaro","sequence":"additional","affiliation":[{"name":"Center for Outcomes Research and Epidemiology and Department of Diagnostic Medicine\/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew C.","family":"Tanner","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"4","key":"B1","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.cvsm.2013.03.012","article-title":"Management of cardiac emergencies in small animals","volume":"43","author":"DeFrancesco TC","year":"2013","unstructured":"DeFrancesco TC. 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