{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T05:36:47Z","timestamp":1677044207923},"reference-count":28,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2023,2,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p content-type=\"noindent\">To determine the plasma concentration of meloxicam delivered via an osmotic pump in pigeons undergoing orthopedic surgery and if an osmotic pump is a suitable alternative to repeated oral administration of this drug.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p content-type=\"noindent\">16 free-ranging pigeons presented for rehabilitation with a wing fracture.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p content-type=\"noindent\">An osmotic pump filled with 0.2 mL of 40 mg\/mL meloxicam injectable solution was implanted subcutaneously in the inguinal fold of 9 pigeons under anesthesia for orthopedic surgery. The pumps were removed 7 days postsurgery. Blood samples were collected before pump implantation (time 0) and 3, 24, 72, and 168 hours after pump implantation in 2 pigeons in a pilot study then at 12, 24, 72, and 144 hours in the 7 pigeons of the main study. The blood of 7 other pigeons receiving meloxicam at 2 mg\/kg, PO, every 12 hours was also sampled between 2 to 6 hours after the last meloxicam administration. Plasma meloxicam concentrations were measured via high-performance liquid chromatography.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p content-type=\"noindent\">The plasma concentration of meloxicam was maintained at significant levels from 12 hours to 6 days after osmotic pump implantation. Median and minimum plasma concentrations in implanted pigeons were maintained at the same or higher level than those measured in pigeons that received meloxicam at a dose known to be analgesic in this species. No adverse effects attributable to either osmotic pump implantation and removal or meloxicam delivery were observed in this study.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p content-type=\"noindent\">Plasma concentrations levels of meloxicam in pigeons implanted with osmotic pumps were maintained at a similar concentration or higher than the suggested analgesic meloxicam plasma concentration in this species. Thus, osmotic pumps could represent a suitable alternative to the frequent capture and handling of birds for analgesic drug administration.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.22.11.0203","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T13:34:42Z","timestamp":1676986482000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Osmotic pump maintains plasma concentrations of meloxicam for 6 days after orthopedic surgery in pigeons (Columba livia)"],"prefix":"10.2460","author":[{"given":"Thomas","family":"Coutant","sequence":"first","affiliation":[{"name":"Service NAC, CHV Fr\u00e9gis, Arcueil, France"},{"name":"Service NAC, CHUV-Ac, ENVA, Maisons-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciro","family":"Cococcetta","sequence":"additional","affiliation":[{"name":"Service NAC, CHV Fr\u00e9gis, Arcueil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Prouillac","sequence":"additional","affiliation":[{"name":"UPSP Interactions Cellules Environnement (ICE), VetAgro Sup\u2013Campus V\u00e9t\u00e9rinaire de Lyon, Marcy l\u2019\u00e9toile, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadette","family":"Espana","sequence":"additional","affiliation":[{"name":"UPSP Interactions Cellules Environnement (ICE), VetAgro Sup\u2013Campus V\u00e9t\u00e9rinaire de Lyon, Marcy l\u2019\u00e9toile, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Le Barzic","sequence":"additional","affiliation":[{"name":"Chuv-Faune Sauvage, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, Maisons-Alfort, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Arn\u00e9","sequence":"additional","affiliation":[{"name":"Chuv-Faune Sauvage, Ecole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort, Maisons-Alfort, France"},{"name":"Equipe Dynamyc, UPEC, Anses, EnvA, Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh","family":"Huynh","sequence":"additional","affiliation":[{"name":"Service NAC, CHV Fr\u00e9gis, Arcueil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"1","key":"B1","series-title":"J Avian Med Surg","first-page":"1","article-title":"Evaluation of the thermal antinociceptive effects of a sustained-release buprenorphine formulation after intramuscular administration to American kestrels (Falco sparverius)","volume":"32","author":"Guzman DSM","year":"2018","unstructured":"Guzman DSM, Ceulemans SM, Beaufr\u00e8re H, Olsen GH, Paul-Murphy JR. 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