{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:07:16Z","timestamp":1783721236122,"version":"3.55.0"},"reference-count":46,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2023,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Treatment of orofacial tumors in dogs is associated with high morbidity and reliable prognostic factors are lacking. Dynamic contrast-enhanced computed tomography (DCECT) can be used to assess tumor perfusion. The objectives of this study were to describe the perfusion parameters of different types of orofacial tumors and to describe the changes in perfusion parameters during radiotherapy (RT) in a subset of them.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>11 dogs with orofacial tumors prospectively recruited.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>CLINICAL PRESENTATION AND PROCEDURES<\/jats:title>\n<jats:p>All dogs had baseline DCECT to assess blood volume (BV), blood flow (BF), and transit time (TT). Five dogs had repeat DCECT during megavoltage RT.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>5 squamous cell carcinomas, 3 sarcomas, 1 melanoma, 1 histiocytic sarcoma, and 1 acanthomatous ameloblastoma were included. Blood volume and BF were higher in squamous cell carcinomas than in sarcomas, although no statistical analysis was performed. At repeat DCECT, 4 dogs showed a reduction in the size of their tumor during RT. Among these dogs, 3 showed an increase in BV and BF and 1 a decrease in these parameters between the baseline and the follow-up DCECT. The only dog whose tumor increased in size between the first and the second DCECT showed a decrease in BV and BF.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Perfusion parameters derived from DCECT were described in a series of dogs with various types of orofacial tumors. The results suggest that epithelial tumors could have higher BV and BF than mesenchymal tumors, although larger sample sizes are needed to support these preliminary findings.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.22.12.0207","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T12:29:11Z","timestamp":1679920151000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["Dynamic contrast-enhanced computed tomography in 11 dogs with orofacial tumors"],"prefix":"10.2460","author":[{"given":"Jeremy R.","family":"Mortier","sequence":"first","affiliation":[{"name":"Small Animal Teaching Hospital, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, United Kingdom"},{"name":"Diagnostic Imaging Section, Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Li\u00e8ge"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Maddox","sequence":"additional","affiliation":[{"name":"Small Animal Teaching Hospital, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Blackwood","sequence":"additional","affiliation":[{"name":"Small Animal Teaching Hospital, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"La Fontaine","sequence":"additional","affiliation":[{"name":"The Netherlands Cancer Institute, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Busoni","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Section, Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Li\u00e8ge"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"B1","series-title":"Vet Radiol Ultrasound","first-page":"147","article-title":"Computed tomographic characteristics of odontogenic neoplasms in dogs","volume":"55","author":"Amory JT","year":"2014","unstructured":"Amory JT, Reetz JA, S\u00e1nchez MD, et al. 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