{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T05:16:21Z","timestamp":1677215781310},"reference-count":46,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2023,2,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p content-type=\"noindent\">To perform a pilot study with the intent of assessing the feasibility of a modified subchondroplasty (mSCP) technique in a validated preclinical equine model of full-thickness articular cartilage loss and evaluate the short-term patient response to the injected materials.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p content-type=\"noindent\">3 adult horses.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p content-type=\"noindent\">Two 15-mm-diameter full-thickness cartilage defects were created on the medial trochlear ridge of each femur. Defects were treated with microfracture and then filled by 1 of 4 techniques: (1) autologous fibrin graft (FG) via subchondral injection of fibrin glue (FG), (2) autologous fibrin graft via direct injection of FG, (3) subchondral injection of a calcium phosphate bone substitute material (BSM) with direct injection of FG, and (4) untreated control. Horses were euthanized after 2 weeks. Patient response was evaluated via serial lameness examination, radiography, magnetic resonance imaging, computed tomography, gross evaluation, microcomputed tomography, and histopathology.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p content-type=\"noindent\">All treatments were successfully administered. The injected material perfused through the underlying bone into the respective defects without adversely affecting the surrounding bone and articular cartilage. Increased new bone formation was seen at the margins of the trabecular spaces containing BSM. There was no treatment effect on the amount or composition of tissue within defects.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p content-type=\"noindent\">The mSCP technique was a simple, well-tolerated technique in this equine articular cartilage defect model without significant adverse effects to host tissues after 2 weeks. Larger studies with long-term follow-ups are warranted.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.22.12.0219","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T13:33:00Z","timestamp":1677159180000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of a modified subchondroplasty technique in an equine full-thickness cartilage defect model: a pilot study"],"prefix":"10.2460","author":[{"given":"Lauren E.","family":"Smanik","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt T.","family":"Selberg","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary L.","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Brock","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly L.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie R.","family":"Goodrich","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher E.","family":"Kawcak","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"B1","series-title":"Equine Surgery","first-page":"1326","article-title":"Synovial joint biology and pathobiology","author":"Frisbie D","year":"2019","unstructured":"Frisbie D, Johnson S. 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