{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:11:22Z","timestamp":1777605082439,"version":"3.51.4"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2023,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p><jats:italic>Brucella canis<\/jats:italic> is a zoonotic bacterial pathogen of dogs that is notoriously difficult to diagnose and treat. Humans can become infected with <jats:italic>B canis<\/jats:italic> when an infected pet dog is brought into their home. Our objectives were to describe the clinical presentation and outcomes in dogs treated for <jats:italic>B canis<\/jats:italic> and evaluate the performance of the quantitative serologic canine <jats:italic>Brucella<\/jats:italic> multiplex (CBM) assay for monitoring treatment response.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>Diagnostic records from the Animal Health Diagnostic Center at Cornell University were retrospectively reviewed (2017\u20132022) for dogs that underwent repeat <jats:italic>B canis<\/jats:italic> serologic testing. Medical records were requested to compare the clinical presentations and outcomes for dogs that underwent treatment for <jats:italic>B canis<\/jats:italic>. Changes in CBM antibody values were compared between dogs with and without resolution of clinical signs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>While treatment protocols varied in the 30 treated dogs meeting the inclusion criteria, poly-antimicrobial therapy was prescribed in 97% (29\/30) of cases. Gait abnormalities, spinal pain, and discospondylitis were the most common clinical abnormalities. A difference (<jats:italic>P<\/jats:italic> value = .0075) in the percent decrease in CBM assay PO1 antibody values was found in dogs with resolved clinical signs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Young dogs presenting with recurring lameness or back pain should be screened for <jats:italic>B canis<\/jats:italic> infection. A 40% decline in CBM assay values 2 to 6 months posttreatment can be supportive of response to treatment. Further prospective studies are needed to determine the ideal <jats:italic>B canis<\/jats:italic> treatment regimen and the magnitude of public health risks associated with maintaining neutered <jats:italic>B canis-<\/jats:italic>infected animals as pets.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.23.01.0014","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T13:24:13Z","timestamp":1678368253000},"page":"1-7","source":"Crossref","is-referenced-by-count":8,"title":["Antibody response over time correlated with treatment outcome in 30 dogs naturally infected with Brucella canis (2017\u20132022)"],"prefix":"10.2460","author":[{"given":"Cassandra","family":"Guarino","sequence":"first","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Franklin-Guild","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Goodrich","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Conklin","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisha","family":"Frye","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toby","family":"Pinn-Woodcock","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"B1","series-title":"Greene\u2019s Infectious Diseases of the Dog and Cat","first-page":"876","article-title":"Canine brucellosis","author":"Davidson A","year":"2022","unstructured":"Davidson A, Sykes J. 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