{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:37:35Z","timestamp":1787503055994,"version":"build-2736575974"},"reference-count":34,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2023,6,16]]},"abstract":"Abstract<\/jats:title>\n \n OBJECTIVE<\/jats:title>\n To report acute and chronic outcomes of cats with chronic kidney disease (CKD) induced by a remnant kidney model.<\/jats:p>\n <\/jats:sec>\n \n ANIMALS<\/jats:title>\n 32 purpose-bred cats (n = 15 female, n = 17 male).<\/jats:p>\n <\/jats:sec>\n \n PROCEDURES<\/jats:title>\n Cats underwent a 2-stage reduction in renal mass through partial arterial ligation of 1 kidney (day 28) and delayed contralateral nephrectomy (day 0), targeting an 11\/12th functional nephrectomy. Acute (days 28 to 29) survival and renal function parameters were compared over time, and the latter were evaluated as predictors for acute mortality. Chronic (days 30 to >1,100) survival, renal function, and morphology were described.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Acutely, renal function deteriorated in all cats (mean \u00b1 SD baseline and day 28 serum creatinine mean concentration, 1.13 \u00b1 0.23 mg\/dL and 3.03 \u00b1 1.20 mg\/dL, respectively;\n P<\/jats:italic>\n < .001; and GFR, 3.22 mL\/min\/kg \u00b1 0.12 and 1.21 mL\/min\/kg \u00b1 0.08, respectively;\n P<\/jats:italic>\n < .001). Seven (22%) cats were euthanized because of clinical signs of uremia after partial nephrectomy. Prenephrectomy renal function tests were not significant indicators for survival during this acute phase. Twenty-five cats entered the chronic phase. Ten cats were euthanized at a median of 163 days from nephrectomy because of progressive renal dysfunction. Median survival times were significantly different when stratified by acute kidney injury grade at day 29. Cats in the chronic phase had clinical courses similar to cats with naturally occurring CKD, and most (13\/15) were in CKD stage 2.\n <\/jats:p>\n <\/jats:sec>\n \n CLINICAL RELEVANCE<\/jats:title>\n The remnant kidney model is effective at reducing kidney function to an extent that mimics important characteristics of spontaneous CKD in cats.<\/jats:p>\n <\/jats:sec>","DOI":"10.2460\/ajvr.23.04.0081","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T08:53:22Z","timestamp":1686560002000},"page":"1-11","source":"Crossref","is-referenced-by-count":5,"title":["A remnant kidney surgery model in cats induces acute and chronic outcomes that mimic spontaneous chronic kidney disease"],"prefix":"10.2460","author":[{"given":"Chad W.","family":"Schmiedt","sequence":"first","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren G.","family":"Beita","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca N.","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00ebva C.M.","family":"Erickson","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney T.","family":"Herrera","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Rissi","sequence":"additional","affiliation":[{"name":"Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy A.","family":"Brown","sequence":"additional","affiliation":[{"name":"Athens Veterinary Diagnostic Laboratory and Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott A.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"},{"name":"Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"B1","series-title":"Vet Pathol","first-page":"309","article-title":"Chronic kidney disease in aged cats: clinical features, morphology, and proposed pathogeneses","volume":"53","author":"Brown CA","year":"2016","unstructured":"Brown CA, Elliott J, Schmiedt CW, et al. 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