{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T17:22:14Z","timestamp":1712078534316},"reference-count":32,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2023,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate skin perfusion in cats receiving dexmedetomidine compared to a placebo.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>9 healthy adult research cats.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>A randomized, blinded, placebo-controlled study design was used. Two sites, the dorsal metatarsus (site: limb) and lateral flank (site: flank), were evaluated with laser speckle contrast imaging (LSCI) at baseline and following administration of dexmedetomidine (1, 3, or 5 mcg\/kg, IV) or a placebo (0.9% saline, IV). Mean speckle contrast (MSC), a surrogate for perfusion, was obtained from LSCI and compared between treatments. Heart rate, sedation score, and body temperature were recorded. Skin perfusion to the flank and limb, reported as MSC, was assessed via LSCI at baseline and at 5, 10, and 15 minutes posttreatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>There was a significant decrease in heart rate (<jats:italic>P<\/jats:italic> &lt; .001) in cats receiving 1, 3, and 5 mcg\/kg dexmedetomidine compared to placebo. There was a significant increase in median sedation score at all time points postsedation compared to baseline (<jats:italic>P<\/jats:italic> &lt; .018). Changes in MSC for the metatarsus were not significantly different between treatments at any time point (<jats:italic>P<\/jats:italic> = .12). For the flank, MSC was significantly higher for cats treated with dexmedetomidine compared to baseline (<jats:italic>P<\/jats:italic> \u2264 .01). Skin perfusion to the flank decreased as early as 5 minutes posttreatment with dexmedetomidine and persisted for at least 15 minutes, regardless of dexmedetomidine dose.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Dexmedetomidine decreased skin perfusion in cats, even at low doses. Veterinarians may elect for an alternative sedative medication when decreased skin perfusion is a concern.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.23.06.0137","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T14:35:21Z","timestamp":1697121321000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Sedation with dexmedetomidine decreases skin perfusion in cats"],"prefix":"10.2460","author":[{"given":"Danielle L.","family":"Hollenbeck","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley T.","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Scallan","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelley M.","family":"Thieman-Mankin","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Miller","sequence":"additional","affiliation":[{"name":"Dynamic Light Inc, Austin, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew K.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Dynamic Light Inc, Austin, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanna M.","family":"Dickerson","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"12","key":"B1","series-title":"J Small Anim Pract","first-page":"698","article-title":"Indications, outcome and complications with axial pattern skin flaps in dogs and cats: 73 cases","volume":"56","author":"Field EJ","year":"2015","unstructured":"Field EJ, Kelly G, Pleuvry D, Demetriou J, Baines SJ. 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Microvasc Res. 2011;82(2):147\u2013151. doi:10.1016\/j.mvr.2011.06.006"},{"issue":"4","key":"B14","series-title":"J Plast Reconstr Aesthet Surg","first-page":"611","article-title":"Investigation of blood perfusion by laser speckle contrast imaging in stretched and rotated skin flaps in a porcine model","volume":"71","author":"Nguyen CD","year":"2018","unstructured":"Nguyen CD, Sheikh R, Dahlstrand U, Lindstedt S, Malmsjo M. Investigation of blood perfusion by laser speckle contrast imaging in stretched and rotated skin flaps in a porcine model. 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