{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:21:07Z","timestamp":1790623267678,"version":"4.1.0"},"reference-count":29,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>Effect of photobiomodulation therapy (PBMT) in patients with CCLR after TPLO surgery by measuring C-reactive protein (CRP), percentage weight bearing, lameness using a short form of a composite measure pain scale, evaluated by the clinician and owners, and surgical site infection.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>SAMPLE<\/jats:title>\n<jats:p>54 client-owned dogs with CCLR undergoing unilateral TPLO surgery were enrolled in this study between April 5, 2021, through April 10, 2022.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>The study population was randomly assigned to either a treatment group receiving PMBT (24 dogs) or a control group (30 dogs). PMBT was performed on the treatment group immediately after induction, and 6 hours, 24 hours, 48 hours, and 8 weeks postoperatively. The control group received sham PMBT (device turned off) at the same time. Evaluation of CRP, CMPS-SF, evidence of SSI, and %WB were evaluated for all dogs 24 hours preoperatively, and then 24 hours, 48 hours, and 8 weeks postoperatively. Owners completed CMPS-SF and subjective evaluations weekly for 8 weeks postoperatively.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>No statistically significant differences were found between treatment groups when evaluating CRP, %WB, and CMPS-SF by the clinician and weekly evaluation of the CMPS-SF by owners. Although no statistically significant differences were found in patients developing surgical site infections between treatment groups, SSI was only observed in patients in the control group (5\/30, 16.6%). Most were minor\/superficial infections (4\/30 13.3%), and a single dog (1\/30, 3.3%) had a major\/deep surgical site infection.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Although with promising but not statistically significant differences between groups, surgical site infections may be reduced after PBMT application.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.23.06.0138","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T13:16:25Z","timestamp":1701436585000},"source":"Crossref","is-referenced-by-count":7,"title":["Photobiomodulation therapy in dogs undergoing TPLO after cranial cruciate ligament rupture shows promise but no statistically significant difference in a randomized trial"],"prefix":"10.2460","volume":"85","author":[{"given":"Oscar A.","family":"Chavez","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Renberg","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Cernicchiaro","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"3","key":"B1","series-title":"Physiotherapy","first-page":"161","article-title":"A review of low level laser therapy","volume":"77","author":"Kitchen SS","year":"1991","unstructured":"Kitchen SS, Partridge CJ. 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Dermatol Surg. 2005;31(3):334\u2013340. doi:10.1111\/j.1524-4725.2005.31086"},{"issue":"9705","key":"B4","series-title":"Lancet","first-page":"1897","article-title":"Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials [published correction appears in Lancet. 2010 Mar 13;375(9718):894]","volume":"374","author":"Chow RT","year":"2009","unstructured":"Chow RT, Johnson MI, Lopes-Martins RA, Bjordal JM. Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials [published correction appears in Lancet. 2010 Mar 13;375(9718):894]. Lancet. 2009;374(9705):1897\u20131908. doi:10.1016\/S0140-6736(09)61522-1"},{"issue":"3","key":"B5","series-title":"J Photochem Photobiol B","first-page":"219","article-title":"Irradiation with He-Ne laser increases ATP level in cells cultivated in vitro","volume":"27","author":"Karu T","year":"1995","unstructured":"Karu T, Pyatibrat L, Kalendo G. Irradiation with He-Ne laser increases ATP level in cells cultivated in vitro. J Photochem Photobiol B. 1995;27(3):219\u2013223. doi:10.1016\/1011-1344(94)07078-3"},{"issue":"1","key":"B6","series-title":"Biochem Mol Biol Int","first-page":"149","article-title":"Stimulation of ATP synthesis via oxidative phosphorylation in wheat mitochondria irradiated with helium-neon laser","volume":"39","author":"Pastore D","year":"1996","unstructured":"Pastore D, Di Martino C, Bosco G, Passarella S. Stimulation of ATP synthesis via oxidative phosphorylation in wheat mitochondria irradiated with helium-neon laser. 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