{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T04:25:40Z","timestamp":1750393540412},"reference-count":27,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2023,8,14]]},"abstract":"Abstract<\/jats:title>\n\nOBJECTIVE<\/jats:title>\nEvaluate agreement among the antimicrobial susceptibility profiles of Mannheimia haemolytica<\/jats:italic> or Pasteurella multocida<\/jats:italic> obtained by transtracheal wash, nasal swab, nasopharyngeal swab, and bronchoalveolar lavage.<\/jats:p>\n<\/jats:sec>\n\nANIMALS<\/jats:title>\n100 Holstein and Holstein-cross bull calves with bovine respiratory disease.<\/jats:p>\n<\/jats:sec>\n\nMETHODS<\/jats:title>\nCalves > 30 days old with naturally occurring bovine respiratory disease were sampled sequentially by nasal swab, nasopharyngeal swab, transtracheal wash, and then bronchoalveolar lavage. Samples were cultured, and for each antimicrobial, the MIC of 50% and 90% of isolates was calculated, and isolates were categorized as susceptible or not. Categorical discrepancies were recorded. Percent positive agreement and kappa values were calculated between isolates for each of the sampling methods.<\/jats:p>\n<\/jats:sec>\n\nRESULTS<\/jats:title>\nAntimicrobial susceptibility varied by pathogen and resistance to enrofloxacin, florfenicol, tilmicosin, and spectinomycin was detected. Minor discrepancies were seen in up to 29% of classifications, with enrofloxacin, penicillin, and florfenicol more frequently represented than other drugs. Very major and major discrepancies were seen when comparing florfenicol (1.9%) and tulathromycin (3.8 to 4.9%) across sampling methods. Some variability was seen in agreement for enrofloxacin for several comparisons (8.3 to 18.4%).<\/jats:p>\n<\/jats:sec>\n\nCLINICAL RELEVANCE<\/jats:title>\nSusceptibility testing of isolates from 1 location of the respiratory tract can reliably represent susceptibility in other locations. Nevertheless, the potential for imperfect agreement between sampling methods does exist. The level of restraint available, the skill level of the person performing the sampling, the age and size of the animal, disease status, and treatment history all must be factored into which test is most appropriate for a given situation.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.23.06.0140","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T13:47:32Z","timestamp":1691588852000},"page":"1-9","source":"Crossref","is-referenced-by-count":1,"title":["Agreement of antimicrobial susceptibility testing of Pasteurella multocida and Mannheimia haemolytica isolates from preweaned dairy calves with bovine respiratory disease"],"prefix":"10.2460","author":[{"given":"Brent C.","family":"Credille","sequence":"first","affiliation":[{"name":"Food Animal Health and Management Program, Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah F.","family":"Capik","sequence":"additional","affiliation":[{"name":"Texas A&M AgriLife Research, Texas A&M University System, Amarillo, TX"},{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Credille","sequence":"additional","affiliation":[{"name":"Food Animal Health and Management Program, Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beate M.","family":"Crossley","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, University of California-Davis, Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pat","family":"Blanchard","sequence":"additional","affiliation":[{"name":"California Animal Health and Food Safety Laboratory System, University of California-Davis, Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia R.","family":"Woolums","sequence":"additional","affiliation":[{"name":"Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry W.","family":"Lehenbauer","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California-Davis, Tulare, CA"},{"name":"Department of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"B1","year":"2007","unstructured":"National Animal Health Monitoring System (NAHMS). 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