{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:00:42Z","timestamp":1778864442938,"version":"3.51.4"},"reference-count":44,"publisher":"American Veterinary Medical Association (AVMA)","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2023,10,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To determine the effects of cardiac cachexia on the metabolomic profile in dogs with myxomatous mitral valve disease (MMVD).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>3 groups of dogs with MMVD enrolled between November 30, 2018, and April 7, 2022: (1) Dogs with congestive heart failure (CHF) and cachexia (CHF-cachexia group; n = 10); (2) dogs with CHF that had no cachexia (CHF-no cachexia group; n = 10); and (3) dogs with asymptomatic disease (American College of Veterinary Internal Medicine [ACVIM] Stage B2) with no cachexia (B2 group; n = 10).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>Metabolomic profiles were analyzed from serum samples using ultra-high-performance liquid chromatography-tandem mass spectroscopy. Dogs in the 3 groups were compared, with statistical significance defined as <jats:italic>P<\/jats:italic> &lt; .05 with a low false discovery rate (<jats:italic>q<\/jats:italic> &lt; .10) and nominal statistical significance defined as <jats:italic>P<\/jats:italic> &lt; .05 but <jats:italic>q<\/jats:italic> &gt; .10.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Numerous metabolites were significantly (n = 201) or nominally significantly (n = 345) different between groups. For example, when comparing the CHF-cachexia vs CHF-no cachexia groups, lipids were the predominant metabolite differences, including many medium- and long-chain dicarboxylates and dicarboxylate acylcarnitines. For comparisons of the CHF-cachexia vs B2 groups and the CHF-no cachexia vs B2 groups, amino acids, nucleotides, and cofactors\/vitamins were the predominant metabolite differences.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Some significant metabolite differences were identified between dogs with and without cardiac cachexia.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.23.07.0161","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T12:32:23Z","timestamp":1696595543000},"page":"1-10","source":"Crossref","is-referenced-by-count":3,"title":["Untargeted metabolomic profiling of dogs with myxomatous mitral valve disease and congestive heart failure shows metabolic differences associated with the presence of cardiac cachexia"],"prefix":"10.2460","author":[{"given":"Lisa M.","family":"Freeman","sequence":"first","affiliation":[{"name":"Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Rush","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily T.","family":"Karlin","sequence":"additional","affiliation":[{"name":"Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"1","key":"B1","series-title":"J Vet Intern Med","first-page":"3","article-title":"Cachexia and sarcopenia: emerging syndromes of importance in dogs and cats","volume":"26","author":"Freeman LM","year":"2011","unstructured":"Freeman LM. 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