{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:57:43Z","timestamp":1791907063993,"version":"4.3.4"},"reference-count":38,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To investigate the role of curcumin in the regulation of P-glycoprotein (P-gp) and its influence on the pharmacokinetics of P-gp substrates.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>SAMPLE<\/jats:title>\n<jats:p>39 broiler chicken and chicken embryonic primary hepatocytes.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>Chicken embryonic primary hepatocytes were treated with curcumin, after which cell viability, P-gp expression, and transport were assessed. Broiler chickens were pretreated with curcumin, after which P-gp expression and the pharmacokinetic behavior of orally administered sulfadiazine (a substrate of P-gp) were measured.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The preliminary results showed that the viability of chicken embryonic primary hepatocytes was enhanced by pretreatment with 40, 60, and 100 \u03bcM curcumin. Curcumin inhibits the expression and transport of P-gp. In vivo experiments showed that curcumin decreased the expression of P-gp in the broiler chicken liver, kidney, and small intestine. Pretreatment with curcumin changed the pharmacokinetic behavior of orally administered sulfadiazine by increasing the area under the curve (47.36 vs 70.35 h\u00b7mg\/L, <jats:italic>P<\/jats:italic> &lt; .01) and peak concentration (10.1 vs 14.53 \u03bcg\/mL, <jats:italic>P<\/jats:italic> &lt; .01).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Curcumin inhibited the expression and efflux of chicken P-gp, thereby improving the oral bioavailability of P-gp substrate drugs. These findings provide a rationale for exploiting herbal-drug interactions in veterinary practice to improve the absorption of drugs.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.23.09.0210","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T13:39:33Z","timestamp":1708954773000},"source":"Crossref","is-referenced-by-count":2,"title":["Inhibitor of P-glycoprotein\u2013mediated drug transport by curcumin in broiler chickens"],"prefix":"10.2460","volume":"85","author":[{"given":"Mei","family":"Li","sequence":"first","affiliation":[{"name":"School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maynur","family":"Abdurexit","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyong","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"8","key":"B1","series-title":"Naunyn Schmiedebergs Arch Pharmacol","first-page":"1621","article-title":"Acquired ABC-transporter overexpression in cancer cells: transcriptional induction or Darwinian selection?","volume":"394","author":"Theile D","year":"2021","unstructured":"Theile D, Wizgall P. 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