{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T04:20:40Z","timestamp":1727842840457},"reference-count":59,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To investigate the role of equine herpesvirus-2 (EHV-2) and equine herpesvirus-5 (EHV-5) in equine glandular gastric disease (EGGD) by visualizing and quantifying these gamma herpesviruses in EGGD-affected and normal glandular gastric mucosa of horses. A secondary objective was to describe the histopathological abnormalities in the equine gastric glandular mucosa in horses with EGGD.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>29 horses (n = 21 postmortem and 8 gastroscopy) categorized as normal (11), EGGD (12), or both EGGD and equine squamous gastric disease (6).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>Glandular gastric mucosal samples were collected from horses by gastroscopy or postmortem. Histopathology and in situ hybridization targeting EHV-2 and EHV-5 were performed on grossly normal and abnormal glandular gastric mucosa. The number of in situ hybridization-positive cells per millimeter squared of tissue was calculated. Evaluators were blinded to groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Glandular gastric tissues from horses without EGGD had higher viral loads in the mucosa than normal or abnormal tissues from EGGD horses. There was no difference in viral loads for EHV-2 or EHV-5 between grossly or endoscopically normal to abnormal gastric tissues within horses with EGGD. Lymphocytic plasmacytic gastritis was the most common histopathological abnormality, with only 3 horses having mucosal disruption (glandular ulcer or erosion).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Equine gamma herpesviruses are unlikely to play a role in the pathophysiology of EGGD. EGGD is frequently inflammatory with occasional mucosal disruption (ulcer or erosion).<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.23.12.0282","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T13:22:11Z","timestamp":1710422531000},"source":"Crossref","is-referenced-by-count":2,"title":["Equine gamma herpesvirus presence and viral load are not associated with equine glandular gastric disease"],"prefix":"10.2460","volume":"85","author":[{"given":"Rachelle N.","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Pearson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean P.","family":"McDonough","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helenrose","family":"Iannitti","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerlinde R.","family":"Van de Walle","sequence":"additional","affiliation":[{"name":"Baker Institute for Animal Health, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Banse","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian A.","family":"Perkins","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy E.","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Baker Institute for Animal Health, Cornell University, Ithaca, NY"},{"name":"Department of Clinical Studies, University of Pennsylvania, Kennett Square, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"7","key":"B1","series-title":"Animals (Basel)","first-page":"1261","article-title":"Equine gastric ulcer syndrome: an update on current knowledge","volume":"13","author":"Vokes J","year":"2023","unstructured":"Vokes J, Lovett A, Sykes B. 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