{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:34:21Z","timestamp":1773326061014,"version":"3.50.1"},"reference-count":49,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2024,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>The aim of this study was to investigate the roles of ribonucleotide reductase subunit M2 (RRM2; subunit of ribonucleotide reductase) in severe woody breast (WB) and normal breast muscles.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>40 8-week-old male Ross-708 broiler chickens.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>Quantitative PCR was performed to determine gene expression, and commercial ELISA\/assay kits were used to obtain several enzymatic activities.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Results showed that RRM2 activity (<jats:italic>P<\/jats:italic> = .0002) and RRM2 (<jats:italic>P<\/jats:italic> = .05) and hydroxymethylbilane synthase expression (impaired oxygen transport and metabolism, <jats:italic>P<\/jats:italic> = .002) were reduced in WB, while caveolin-3 (defected membrane integrity, <jats:italic>P<\/jats:italic> = .09), endoglin (increased fibrosis, <jats:italic>P<\/jats:italic> = .06), and secreted protein acidic rich in cysteine (metabolic dysregulation, <jats:italic>P<\/jats:italic> = .09) expression tended to increase in WB. WB tended to have increased levels of homocysteine (<jats:italic>P<\/jats:italic> = .06), aspartate aminotransferase mitochondria (<jats:italic>P<\/jats:italic> = .02), pyruvate kinase (<jats:italic>P<\/jats:italic> = .04), DNA damage (<jats:italic>P<\/jats:italic> = .06), creatine kinase (<jats:italic>P<\/jats:italic> = .05), and triglyceride (<jats:italic>P<\/jats:italic> = .002) but decreased ATPase activity (<jats:italic>P<\/jats:italic> = .01), all indicating mitochondria dysfunction and tissue damage.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>In this study, differences in various enzyme activities and increased DNA damage suggest that RRM2-mediated mitochondrial abnormalities may play a role in WB myopathy.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.23.12.0283","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T16:43:34Z","timestamp":1708447414000},"source":"Crossref","is-referenced-by-count":9,"title":["Reduced ribonucleotide reductase RRM2 subunit expression increases DNA damage and mitochondria dysfunction in woody breast chickens"],"prefix":"10.2460","volume":"85","author":[{"given":"Majid","family":"Shakeri","sequence":"first","affiliation":[{"name":"USDA-ARS, U.S. National Poultry Research Center, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janghan","family":"Choi","sequence":"additional","affiliation":[{"name":"USDA-ARS, U.S. National Poultry Research Center, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin","family":"Harris","sequence":"additional","affiliation":[{"name":"USDA-ARS, U.S. National Poultry Research Center, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard Jeff","family":"Buhr","sequence":"additional","affiliation":[{"name":"USDA-ARS, U.S. National Poultry Research Center, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byungwhi","family":"Kong","sequence":"additional","affiliation":[{"name":"USDA-ARS, U.S. National Poultry Research Center, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhuang","sequence":"additional","affiliation":[{"name":"USDA-ARS, U.S. National Poultry Research Center, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Bowker","sequence":"additional","affiliation":[{"name":"USDA-ARS, U.S. National Poultry Research Center, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"B1","series-title":"Front Vet Sci","first-page":"497","article-title":"Characterizing woody breast myopathy in a meat broiler line by heat production, microbiota, and plasma metabolites","volume":"6","author":"Maharjan P","year":"2020","unstructured":"Maharjan P, Hilton K, Weil J, et al. 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