{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T19:06:51Z","timestamp":1774724811124,"version":"3.50.1"},"reference-count":49,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate the relationships between the severity of myxomatous mitral valve disease (MMVD) and pulmonary hypertension (PH) and serum angiopoietin (Ang)-1 and Ang-2 concentrations in dogs with MMVD.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>74 dogs (control, n = 12; MMVD, n = 62) were included.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>Serum Ang-1 and Ang-2 concentrations were estimated using the canine-specific ELISA kit. The concentrations were compared between dogs with MMVD and healthy dogs, and they were analyzed according to the severity of MMVD and PH.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>The median serum Ang-1 concentration did not differ among the study groups. The median serum Ang-2 concentration was higher in dogs with stage B2 MMVD (<jats:italic>P<\/jats:italic> = .041) and acute congestive heart failure (<jats:italic>P<\/jats:italic> = .002) than in control dogs. In addition, the median serum Ang-2 concentration was higher in MMVD dogs with PH than in those without PH (<jats:italic>P<\/jats:italic> = .031). Serum Ang-2 concentration was correlated with vertebral heart score (<jats:italic>r<jats:sub>s<\/jats:sub><\/jats:italic> = 0.36, <jats:italic>P<\/jats:italic> = .004) and vertebral left atrial score (<jats:italic>r<\/jats:italic> = 0.50, <jats:italic>P<\/jats:italic> &lt; .001) in dogs with MMVD, and correlated with vertebral heart score (<jats:italic>r<\/jats:italic> = 0.63, <jats:italic>P<\/jats:italic> = .01), maximum E wave amplitude of the diastolic transmitral flow (<jats:italic>r<jats:sub>s<\/jats:sub><\/jats:italic> = 0.61, <jats:italic>P<\/jats:italic> = .018), ejection fraction (<jats:italic>r<jats:sub>s<\/jats:sub><\/jats:italic> = \u20130.77, <jats:italic>P<\/jats:italic> &lt; .001) and fractional shortening (<jats:italic>r<jats:sub>s<\/jats:sub><\/jats:italic> = \u20130.56, <jats:italic>P<\/jats:italic> = .032) in dogs with acute congestive heart failure.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Circulating Ang-2 levels increase in dogs with the severity of MMVD and the presence of PH.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.23.12.0289","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T12:14:57Z","timestamp":1711455297000},"source":"Crossref","is-referenced-by-count":2,"title":["Myxomatous mitral valve disease and associated pulmonary hypertension might increase serum angiopoietin-2 in dogs"],"prefix":"10.2460","volume":"85","author":[{"given":"Hogeun","family":"Yu","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dohee","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon","family":"Chae","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minseok","family":"Choi","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yelim","family":"Lee","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taesik","family":"Yun","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong-Teck","family":"Kang","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mhan-Pyo","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakhyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"12","key":"B1","series-title":"Trends Immunol","first-page":"552","article-title":"Angiopoietins: a link between angiogenesis and inflammation","volume":"27","author":"Fiedler U","year":"2006","unstructured":"Fiedler U, Augustin HG. 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