{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:45:08Z","timestamp":1783035908830,"version":"3.54.6"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To determine if tissue oxygen saturation (StO<jats:sub>2<\/jats:sub>) correlates with oxygen delivery (DO<jats:sub>2<\/jats:sub>) and\/or cardiac output (CO) in a canine hemorrhagic shock model.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>8 healthy purpose-bred dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>Dogs were anesthetized, and hemorrhagic shock was induced by withdrawing up to 60% of total blood volume, targeting a mean arterial pressure (MAP) of 40 mm Hg. The withdrawn blood was returned to the patient in 2 equal aliquots. Data was collected at 4 time points: 10 minutes after MAP was stabilized under anesthesia (time point [TP]-1), 10 minutes after up to 60% of blood volume was removed to target a MAP of 40 mm Hg (TP2), 10 minutes after the return of 50% of shed blood (TP3), and 10 minutes after the return of the remaining 50% of shed blood (TP4). Total blood volume withdrawn, StO<jats:sub>2<\/jats:sub>, CO, heart rate, and MAP were recorded, and DO<jats:sub>2<\/jats:sub> was calculated at each TP.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Mean StO<jats:sub>2<\/jats:sub> significantly decreased between TP1 (77.8% [\u00b1 9.54]) and TP2 (44.8% [\u00b1 19.5]; <jats:italic>P<\/jats:italic> &lt; .001 vs TP1). Mean StO<jats:sub>2<\/jats:sub> increased to 63.1% (\u00b1 9.85) at TP3, but remained significantly lower compared to TP1 (<jats:italic>P =<\/jats:italic> .002). There was no difference between mean StO<jats:sub>2<\/jats:sub> at TP4 (82.5% [\u00b1 12.6]) versus TP1 (<jats:italic>P =<\/jats:italic> .466). StO<jats:sub>2<\/jats:sub> has a strong, positive correlation to both CO (<jats:italic>r<\/jats:italic> = 0.80; <jats:italic>P<\/jats:italic> &lt; .001) and DO<jats:sub>2<\/jats:sub> (<jats:italic>r<\/jats:italic> = 0.75; <jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>A decrease in StO<jats:sub>2<\/jats:sub> may be used in conjunction with physical examination findings and diagnostic parameters to support a diagnosis of shock. The return of shed blood was correlated with increases in StO<jats:sub>2<\/jats:sub>, DO<jats:sub>2<\/jats:sub>, and CO, suggesting that StO<jats:sub>2<\/jats:sub> may be used as a marker of adequate resuscitation.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.23.12.0297","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T19:40:46Z","timestamp":1714419646000},"source":"Crossref","is-referenced-by-count":1,"title":["Tissue oxygen saturation is positively correlated with oxygen delivery and cardiac output in a canine hemorrhagic shock and resuscitation model"],"prefix":"10.2460","volume":"85","author":[{"given":"Taylor N.","family":"Baird","sequence":"first","affiliation":[{"name":"Department of Clinical Science, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles T.","family":"Talbot","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly E.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Hess","sequence":"additional","affiliation":[{"name":"Department of Statistics, College of Natural Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin M.","family":"Zersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"B1","series-title":"Small Animal Critical Care Medicine","first-page":"26","article-title":"Shock","author":"de Laforcade A","year":"2015","unstructured":"de Laforcade A, Silverstein DC. 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