{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:19:33Z","timestamp":1779376773422,"version":"3.53.1"},"reference-count":54,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To examine the potential of galangin in a mouse model of ovalbumin (OVA)-induced allergic rhinitis (AR), as chronic AR, induced by immunoglobulin-E (IgE), leads to histamine release and nasal inflammation, and although galangin exhibits antiasthmatic and anti-inflammatory potential, its effect on AR is yet to be investigated.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>126 BALB\/c mice.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>AR induction involved sensitizing female mice with OVA (5%, 500 \u00b5L, IP) for 14 days. Post OVA challenge, the mice were divided into 7 groups (n = 18\/group), including normal, AR control, montelukast (10 mg\/kg), galangin (5, 10, and 20 mg\/kg), and per se (galangin [20 mg\/kg] treatment. Various outcomes were evaluated, including nasal symptoms, histopathology, biochemistry, and nasal lavage fluid inflammatory cytokines and signaling pathways in nasal mucosal to assess galangin potential in AR.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>In AR mice, galangin (10 and 20 mg\/kg) significantly (<jats:italic>P<\/jats:italic> &lt; .05) reduced sneezing, rubbing, and nasal discharge post-OVA challenge. Galangin treatment attenuated (<jats:italic>P<\/jats:italic> &lt; .05) elevated serum histamine, \u03b2-hexosaminidase, IgE, and Immunoglobulin G1 levels in AR control mice. Additionally, galangin significantly (<jats:italic>P<\/jats:italic> &lt; .05) decreased OVA-induced alterations in IL-4, IL-6, IL-13, and interferon-\u03b3 levels in nasal lavage fluid compared to AR control mice. Western blot analysis demonstrated that galangin lowered OVA-induced AR by significantly (<jats:italic>P<\/jats:italic> &lt; .05) downregulating the phosphorylated protein kinase B and mammalian target of rapamycin-protein expressions while markedly (<jats:italic>P<\/jats:italic> &lt; .05) upregulating the glycogen synthase kinase-3\u03b2 protein expressions in nasal mucosal. Galangin also significantly ameliorated (<jats:italic>P<\/jats:italic> &lt; .05) the OVA-induced histological aberrations in the nasal mucosa, reflected by reduced eosinophil infiltration, hyperplasia, and edema.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Galangin exhibits antihistaminic and anti-inflammatory effects in AR mice by regulating IgE-mediated histamine and inflammatory release and modulating the phosphatidylinositol 3-kinase\/Ak strain transforming\/mammalian target of rapamycin pathways.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.24.02.0031","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T12:11:38Z","timestamp":1714651898000},"source":"Crossref","is-referenced-by-count":4,"title":["Ameliorative potential of galangin in murine model of ovalbumin-induced allergic rhinitis: a role of PI3K-PKB pathway"],"prefix":"10.2460","volume":"85","author":[{"given":"Jinwei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, XD Group Hospital, Xi'an, Jian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, XD Group Hospital, Xi'an, Jian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"1","key":"B1","series-title":"J Clin Basic Psychosomat","first-page":"0956","article-title":"Assessment of life quality and influencing factors in adults with atopic dermatitis in the northeast of China","volume":"1","author":"Wang H","year":"2023","unstructured":"Wang H, Tian Y, Zhang H, Zhang H, Li B, Bu Z. 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