{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:07:03Z","timestamp":1788998823511,"version":"build-2803163510"},"reference-count":43,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2024,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To determine antibiotic levels in plasma and interstitial fluid (ISF) after SC placement of compounded florfenicol (FF) calcium sulfate beads (CSBs) in New Zealand White rabbits (<jats:italic>Oryctolagus cuniculus<\/jats:italic>).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>6 juvenile female rabbits (n = 5 treatment and 1 control).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>An ultrafiltration probe and CSBs were placed SC in 6 rabbits (n = 5 for FF CSBs and 1 for control CSBs). Plasma (3, 6, 12, 24, and 48 hours and 7, 14, and 21 days) and ISF (daily for 21 days) samples were collected, and FF was measured by HPLC for pharmacokinetic analysis. Hematology, biochemistry, and histopathology were assessed. <\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Means \u00b1 SD for the area under the curve, maximum concentration, time of maximum concentration, terminal half-life, and mean residence time to the last data point for plasma and ISF were 16.63 \u00b1 8.16 and 17,902 \u00b1 7,564 h\u00b7\u00b5g\/mL, 0.79 \u00b1 0.38 and 245 \u00b1 223 \u00b5g\/mL, 2.90 \u00b1 0.3 and 59 \u00b1 40 hours, 30.81 \u00b1 16.9 and 27.3 \u00b1 9.39 hours, 23.4 \u00b1 10 and 73.7 \u00b1 13 hours, respectively. Plasma FF was &lt; 2 \u00b5g\/mL at all time points. The ISF FF remained &gt; 8 \u03bcg\/mL for 109.98 to 231.58 hours. One rabbit death occurred during treatment, but the cause of death was undetermined. Local tissue inflammation was present, but no clinically significant systemic adverse effects were found on hematology, biochemistry, or histopathology in the remaining rabbits.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Florfenicol CSBs maintained antibiotic concentrations in ISF at levels likely to be effective against bacteria sensitive to &gt; 8 \u00b5g\/mL for 5 to 10 days while maintaining low (&lt; 2 \u00b5g\/mL) plasma levels. Florfenicol CSBs may be effective for local antibiotic treatment in rabbit abscesses.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.24.02.0044","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T14:35:50Z","timestamp":1715697350000},"source":"Crossref","is-referenced-by-count":2,"title":["Plasma and interstitial fluid antibiotic levels of subcutaneously implanted compounded florfenicol calcium sulfate beads in New Zealand White rabbits (Oryctolagus cuniculus)"],"prefix":"10.2460","volume":"85","author":[{"given":"Megan","family":"Partyka","sequence":"first","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Divers","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crisanta","family":"Cruz-Espindola","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisia A. 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