{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:55:19Z","timestamp":1780491319910,"version":"3.54.1"},"reference-count":48,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"sc_a1\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To describe serum fibroblast growth factor 23 (FGF-23) concentrations in young adult cats with remnant kidney model\u2013induced chronic kidney disease (CKD) and to evaluate the effects of orally administered aluminum hydroxide (ALOH) on serum phosphate and FGF-23 concentrations in these cats.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a2\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>17 adult, purpose-bred cats with induced CKD and 13 healthy, age-matched cats.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a3\">\n<jats:title>METHODS<\/jats:title>\n<jats:p>A prospective, randomized study. Cats with induced CKD fed a wet renal diet received treatment with ALOH (90 mg\/kg\/d, PO) on days 0 to 42 and no treatment on days 43 to 84 (treatment group, n = 9) or no treatment on days 0 to 84 (control group, n = 8). Standard serum and urine biochemical analyses and several parameters reflective of calcium-phosphate balance, including serum parathyroid hormone and FGF-23 concentrations, were evaluated at baseline and various time points, including days 42 and 84. Age-matched, healthy, community-owned cats underwent similar evaluations at a single time point. Baseline data from CKD cats were compared to those of healthy cats. Longitudinal data from CKD cats were compared over time.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a4\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Serum phosphate, total and ionized calcium, and FGF-23 concentrations were significantly higher in CKD cats at baseline relative to healthy cats (all <jats:italic>P<\/jats:italic> \u2264 .009). Serum phosphate concentration did not change significantly over time in either CKD group; however, FGF-23 concentrations significantly increased over time in the control group (<jats:italic>P<\/jats:italic> &lt; .02) but not the treatment group (<jats:italic>P<\/jats:italic> = .059).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sc_a5\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Aluminum hydroxide did not reduce serum phosphate or FGF-23 concentrations in this small study of cats with induced CKD chronically eating a phosphate-restricted diet.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.24.04.0123","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T13:23:46Z","timestamp":1723555426000},"source":"Crossref","is-referenced-by-count":2,"title":["Effect of aluminum hydroxide on serum phosphate and fibroblast growth factor 23 concentrations in young adult cats with surgically induced chronic kidney disease"],"prefix":"10.2460","volume":"85","author":[{"given":"Keren G.","family":"Beita","sequence":"first","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-4645","authenticated-orcid":true,"given":"Bianca N.","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Rehagen","sequence":"additional","affiliation":[{"name":"Elanco Animal Health GmbH, Monheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad W.","family":"Schmiedt","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"1","key":"B1","series-title":"Vet J","first-page":"18","article-title":"Renal fibrosis in feline chronic kidney disease: known mediators and mechanisms of injury","volume":"203","author":"Lawson J","year":"2015","unstructured":"Lawson J, Elliott J, Wheeler-Jones C, Syme H, Rosanne J. 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