{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:20:10Z","timestamp":1790198410235,"version":"4.1.0"},"reference-count":63,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>Urothelial carcinoma (UC) is the most common urogenital cancer in dogs. With early diagnosis, the disease can be controlled, to reduce progression of disease, in most dogs with a good quality of life. MicroRNAs (miRNAs) have been identified as a potential diagnostic and prognostic tool due to their stability and presence in both bodily fluids and tissues. MiRNAs have been frequently researched in human medicine and human UC; however, few manuscripts regarding miRNAs in canine UC are available. A search was performed on both PubMed and Google Scholar evaluating original research manuscripts with experimentally validated results for the terms \u201ccanine\u201d or \u201cdog\u201d; \u201curothelial carcinoma,\u201d \u201cbladder cancer,\u201d \u201ctransitional cell carcinoma,\u201d \u201cTCC,\u201d \u201cMIBC,\u201d \u201cIMBUC,\u201d or \u201cBLCA\u201d; and \u201cmiRNA\u201d or \u201cmicroRNA.\u201d We identified 3 peer-reviewed manuscripts evaluating miRNA expression in canine UC and compared the reported miRNA expression studies to human UC to identify experimentally validated targets of the dysregulated miRNA. In this review, we highlight the similarities and differences between what is reported in canine UC and human UC and discuss the literature gaps that call for further evaluation.<\/jats:p>","DOI":"10.2460\/ajvr.24.05.0150","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T13:54:27Z","timestamp":1721829267000},"source":"Crossref","is-referenced-by-count":2,"title":["A review of the current standing of microRNA expression in canine urothelial carcinoma"],"prefix":"10.2460","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5759-5020","authenticated-orcid":true,"given":"Mara S.","family":"Varvil","sequence":"first","affiliation":[{"name":"Department of Comparative Pathobiology, Purdue University, Lafayette, IN"},{"name":"Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Pires","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathobiology, Purdue University, Lafayette, IN"},{"name":"Purdue Institute for Cancer Research, West Lafayette, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"2","key":"B1","series-title":"J Vet Intern Med","first-page":"136","article-title":"Canine transitional cell carcinoma","volume":"17","author":"Mutsaers AJ","year":"2003","unstructured":"Mutsaers AJ, Widmer WR, Knapp DW. 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